An intervention directed at durability- of response is considered preventive. The question is once well, how can we stay well and can we reduce the risk of relapse (of the same episode) or recurrence (of a new episode) through some longer term approaches to treatment? Interventions are also preventive if they target the excessive levels of disability that often characterize the mental disorders of older people. As we learn more about the risk factors, etiology, and pathophysiology of mental disorders in late life, it is conceivable that preventive interventions could be directed toward delaying Inhibitors,research,lifescience,medical the onset of disease or even preventing

the onset entirely.20 Infrastructure considerations for public health model studies In order to carry out such studies, whether they are treatment studies, preventive interventions, or rehabilitative interventions, Inhibitors,research,lifescience,medical we need to identify the structural barriers in the ways in which research is organized and to innovate approaches to address these barriers. Researchers Inhibitors,research,lifescience,medical and their laboratories are largely based in academic health centers.

The role of the academic health center is being redefined in the context of health care system reorganization, and access to Paclitaxel patients has become problematic. Patient-oriented research is seen as a particularly fragile enterprise Inhibitors,research,lifescience,medical at this point in time.21,22 There are important opportunities emerging, however. Many academic health centers are part of clinical systems that include community hospitals, primary care and specialty care office practices, and capitated contracts. The nonacademic settings of these Inhibitors,research,lifescience,medical large networks

are where the majority of patients are located. The new challenge for the field is how to turn these clinical and administrative networks into research networks for the development and management of intervention trials. At the same time, the parallel challenge is how to identify the critical elements of academically based protocols and paradigms, and adapt Thymidine kinase them for use in the broader community. Advancement for academic investigators is based on research productivity, usually measured by significant publications and success in developing extramural funding. Large-scale, longitudinal, public-health-oriented studies typically have a very long period of time before important publications are developed, and they usually involve the participation of a large number of investigators. Individual intellectual contributions can be difficult to assess in such projects. If there is a commitment to developing this type of research, the challenge for the field is how to adapt promotion and tenure policies to this situation so as to properly recognize individual contributions.