We found an odds ratio of 6. 604 for low grade HCMV IEA infection and odds ratio for RPA class III and IV was. 8. 2 in patients with low grade HCMV IEA infection. We also found an odds ratio of 9. 5 for RPA class III and IV in patients with low grade HCMV LA infection. However, we did not observe an association with extent of surgery, age, gender and gamma knife treatment for read FAQ overall survival 18 months. No differences were observed in the number of patients with either no or low or moderate to high grade HCMV infection in regards to different therapies, except for gamma knife treatment. In patients with no or low grade HCMV IEA infection, 7 of 19 patients had received gamma knife treatment as compared to 10 of 61 patients with moderate to high grade HCMV IEA infection.

Phenotypic characterization of GBMs Inhibitors,Modulators,Libraries All phenotypic characterizations of other factors exam ined for diagnostic purpose. p53, GFAP, MIB index and mitosis in tissue Inhibitors,Modulators,Libraries sections were performed at the pathol ogy department in our hospital. In patients that survived 18 months, p53 mutations were found in 8 of 12 samples with moderate to high grade HCMV IEA infection as compared with 4 of 13 in patients with no or low grade infection. p53 mutation was detected in 7 of 9 patients with moderate to high grade HCMV LA infection and in 5 of 16 with no or low grade Inhibitors,Modulators,Libraries infection. In patients with overall survival 18 months, p53 mutation was detected in 5 of 19 patients with moderate to high grade HCMV IEA infection and in 1/ 3 with no or low grade infection.

In patients with moderate to high grade HCMV LA infection, p53 muta tion was detected in 5/11 of patients as compared to 1 of 11 patients Inhibitors,Modulators,Libraries with no or low grade HCMV LA infection. While no association between p53 mutations was observed for HCMV IEA, we observed a significant association between HCMV late protein expression and p53 mutations The extent of mitosis and MIB index did not differ sig nificantly between the two groups. All exam ined GBM specimens were positive for GFAP. Discussion The etiology of GBM is unknown and the prognosis for GBM patients is still poor despite recent advances in medical treatment with temozolomide and radiotherapy. In our study, we demonstrate a strong associa tion between HCMV infection grade and overall survi val. In the cohort of GBM patients that survived 18 months, 40% had no or low grade HCMV IEA infection as compared with 8% of patients with overall survival 18 months.

Young age and good neurologic function have been reported to be important prognostic factors in GBM patients. In our study, we observed a significant association between no or low grade Inhibitors,Modulators,Libraries HCMV IEA infection and RPA subclass III VI and survival 18 months. Further regression ana lyses of factors influencing survival of patients with low grade versus high grade HCMV infection in GBM tis sues included, age, extent of resection, gender and RPA subclass. We found an odds selleck catalog ratio of 6. 6 for low grade HCMV infection and 8.