MDA levels in the cecal mucosa were significantly h Forth in the placebo group compared with pentoxifylline and comparable with those observed in healthy GSK1363089 Foretinib xl880 rats. Was no significant difference between placebo and norfloxacin group was observed. 4th Discussion SBP is the hour Most frequent and one of severe infections in patients with cirrhosis, with hospital mortality of 10% to 20%. Long-term oral norfloxacin effective in preventing infection, but is associated with resistance to quinolones. In this study we have determined that an alternative non-antibiotic, oral pentoxifylline, the rate even decreased SBP and prevented BT in cirrhotic rats with ascites with Hnlichen results from the norfloxacin group.
These results are consistent with previous studies showing that pentoxifylline is able to BT in experimental models of h Hemorrhagic shock, intestinal obstruction or acute pancreatitis To prevent. We found that 70% of cirrhotic rats lebensf HIGEN bacteria were in the car. This transfer rate h Ago is observed as in some studies, but Similar to the reported by other authors in rats with cirrhosis with ascites. However, as shown in the low rate of translocation in intact animals, was the high Pr Prevalence of BT will probably not be the result of a technical prejudice, but probably pleased t the limit of very low detection of bacteria by inoculating approximately 85% homogenate in brain-heart broth media. This technique, already reported by our group, is much more sensitive than others. Were in fact over a third of BT episodes only by inoculation of the broth diagnosed.
If only agar plates were considered positive, w Re is the number of cirrhotic rats with BT 14/33, and 42% are reduced. An important finding of our study, the reduction of the IBO in cirrhotic rats Enterobacteriaceae was treated with pentoxifylline. Total and average account cecal Enterobacteriaceae colonies were Similar in the pentoxifylline-treated animals, norfloxacin-treated rats and healthy animals and found significantly lower than in the placebo group. Press Convention Of IBO was probably the most important mechanism for the reduction of BT observed in the pentoxifylline-treated animals involved playing as an IBO Middle finger in the process of BT. In experimental models, BT is almost always associated with the transferred IBO organizations.
Nevertheless, this study has not been performed to evaluate the mechanisms to prevent proliferation. Hypoazidit t dir Siege to the stomach and intestinal maturity are known in order to engender the IBO in cirrhosis. Facilitate the effects of pentoxifylline on these factors deserves further investigation. As mentioned above HNT, we observed that administration of pentoxifylline prevented and reduced LV SBP. Norfloxacin administration induced Similar effects on BT and Pr Prevalence SBP. Previous studies have reported the efficacy of pentoxifylline in preventing BT in other St Requirements, in which the translocation of intestinal bacteria into the systemic circulation extremely widespread, as h Hemorrhagic shock, intestinal obstruction or acute pancreatitis . More importantly, in this study, pentoxifylline, and norfloxacin, completely Ndig abolished, the development of SBP, the h Most frequent infection and is characteristic for bacteria in cirrhosis. This is encouraging