Random checks

of the medical charts were performed by the principal investigator for accuracy and completeness of data collection during the study to compare the actual information and that on the hard copies. All ICD codes and AIS scores were cross checked prior to data entry by the PI and errors were corrected. All Electronic records were cross checked for accuracy and discrepancies noted, however once data entry had taken place, no items were changed, modified, or corrected. Missing or incorrect Inhibitors,research,lifescience,medical items were listed as shown in the Table1. Table 1 Item completion and errors Reports Basic frequency tables were produced on the number of admissions, demographics, mechanism of injuries, ICD -9 coding of injuries, discharge Bortezomib disposition, length of Inhibitors,research,lifescience,medical stay, probability of survival and actual survival. The pilot study protocol was approved by the Ethics Review Committee

of the Aga Khan University. Results Cost of KITR development and pilot testing The development of KITR from concept to operational software took 23months. Inhibitors,research,lifescience,medical The estimated cost for the development of the software was USD 9,600. This included the time of investigators (54% of estimated cost), the cost of software development (16% of estimated), and implementation cost (30% of estimated). The actual cost incurred was the implementation cost Inhibitors,research,lifescience,medical in the form of stipends of research assistant and miscellaneous expenditure. Case ascertainment and item completion Triage and admission/discharge list indicated 946 cases; however, number of records within the case definition was 732 during the study period. The number of cases used for the registry was 542 (74%); reasons included non-availability of charts for review

(n=176), patients still receiving care in hospital during study period (n=3) or insufficient documentation of Inhibitors,research,lifescience,medical injuries to assign AIS scores (n=10). Table1 shows item completion and errors. Some variables which were a part of the registry, were not documented in the medical charts; for instance ethnicity (95%), the amount of IV fluids administered in pre-hospital phase (94%), Safety Equipment (81%) and ED notification prior to arrival of patients (90%). These undocumented variables are entered as “unknown” in the KITR. For those patients who were transferred in, ED was notified in only 8.6% cases. Total 25 data points were found as ADP ribosylation factor erroneous. Errors in AIS and ICD included nine AIS scores (1.7% of all cases) and six ICD codes (1% of all cases) were corrected prior to data entry and other 10 items (Table1) were recognized as wrong data entry at the time of verification of electronic data. Time burden The mean time for data retrieval and entry was 29.5 minutes (range 15–50minutes) per case. Time for data abstraction and hard copy questionnaire completion was 14.