S to T cells after antigen recognition. Reversibility t of the process of calcineurin inhibitors it Opens new M Possibilities for pharmacological modulation of this process in the context of cancer, Autoimmunit t and transplantation. Cell death and diseases 3, E299, doi: 10 1038/cddis. In 2012. 38, online at all AP24534 Ponatinib published 19 April 2012 Subject Category: Experimental Medicine B-cell lymphoma two pharmacological inhibition represents a new principle for controlled blood cancers l of immune responses and effects.

1.2 is of particular interest are clinical and scientific potential of the small molecule Bcl-2 inhibitor ABT-737 and its counterpart Navitoclax bioavailable. 3.4 ABT 737 binds with high affinity t to the anti-apoptotic Bcl-2 family Bcl-2, Bcl XL and Bcl w.
Through this mechanism, preventing it from sequestering agent per apoptotic BH3 proteins, and thus indirectly Aromatase the apoptotic cascade to foreign St. By contrast, may be a low affinity ABT 737 t for Bcl 2 A1, Mcl 1 and Bcl B. These specific molecular binding properties are important for the tissue selectivity and t As a result For the favorable side effect profile of ABT ABT 263 737 and 5, but inclined Nkt their therapeutic power of the lymphoma cells, the A1 and Mcl first 6.7 The physiological regulation of apoptosis in lymphocytes has been extensively studied, 8 and may have a new meaning in the context of therapeutic Ans Appreciate for the selective take on Bcl-2 proteins. By focusing on the T cell compartment, it was shown that the fate of a T cell for expression of a functional T cell receptor 9 and its interaction with antigen-pr Presenting cells is connected.
The combination of signals through the TCR, co-stimulation molecules of the cytokines IL-2 and 15) dynamically modulates the intrinsic and extrinsic pathway of apoptosis of T lymphocytes, and m for may have controlled The central and peripheral T cell selection 10 5 Of particular interest are previous reports of a TCR dependent Independent Upregulation of A1 in the early phase after antigen recognition, the thymocytes and splenocytes activated by apoptosis protects without interfering with the cell proliferation. 16.17 These mechanisms are crucial for the development and maintenance of a functional immune system and may System10 drugs that are affected in the pathway of apoptosis.
This hypothesis is supported by previous reports on the immunomodulatory properties of ABT 737 in various experimental models: ABT 737 has a positive effect on Autoimmunit t and 18 significantly inhibited solid Transplantatabsto UNG mice in M. However, immunosuppression was 2.19 ABT 737 in a model of collagen-induced arthritis only effective in a pr Their preventive, but not in mice M Associated with a disease. 20 In addition, the immunosuppressive activity of ABT 737 in a mouse model of skin transplantation t pleased limited as monotherapy, but significantly increased Ht in combination with cyclosporine A. 19 These data suggest that the pro apoptotic activity t on of ABT 737 lymphoid cells In the context of inflammation and T-cell-activationIn this study GE Is changed, we examined the effect of ABT 737 on activated T cells as part of the h They compared the graft and the graft-versus the h They are immune. We found a unique selectivity t profile of ABT 737 on T-lymphocytes may need during the immune response after a transition