Considering these new findings and GSK1120212 price the paucity of solid evidence supporting the effectiveness of PPV-23, the key question is whether PPV-23 should be replaced by newer and more immunogenic vaccines in the near future. In this

review of the effectiveness of PPV-23 we did not find evidence confirming a clear risk reduction for all-cause pneumonia or pneumococcal disease following PPV-23 immunization. There is a need for a better adult pneumococcal vaccine, and future studies should focus on improving vaccination responses by using new vaccine formulations, such as pneumococcal conjugate vaccines and/or vaccine adjuvants. Financial support was received from Aarhus University and the Foundation for Scandinavian Society for Antimicrobial Chemotherapy. Conflicts of interest: None of the authors has a conflict of interest to declare. “
“Once-daily (qd) antiretroviral therapies improve convenience and adherence. If found to be effective, nevirapine extended release (NVP

XR) will confer this benefit. The TRANxITION trial examined the efficacy and safety of switching virologically suppressed patients from NVP immediate release (NVP IR) 200 mg twice daily to NVP buy PLX4032 XR 400 mg qd. An open-label, parallel-group, noninferiority, randomized (2:1 NVP XR:NVP IR) study was performed. Adult HIV-1-infected patients receiving NVP IR plus a fixed-dose nucleoside reverse transcriptase inhibitor (NRTI) combination of lamivudine (3TC)/abacavir (ABC), tenofovir (TDF)/emtricitabine (FTC) or 3TC/zidovudine Methocarbamol (ZDV) with undetectable viral load (VL) were enrolled in the study. The primary endpoint was continued virological suppression with VL < 50 HIV-1 RNA copies/mL up to week 24 (calculated using a time to loss of virological response algorithm). Cochran's statistic

(background regimen adjusted) was used to test noninferiority. Adverse events (AEs) were recorded. Among 443 randomized patients, continued virological suppression was observed in 93.6% (276 of 295) of NVP XR- and 92.6% (137 of 148) of NVP IR-treated patients, an observed difference of 1% [95% confidence interval (CI) −4.3, 6.0] at 24 weeks of follow-up. Noninferiority (adjusted margin of −10%) of NVP XR to NVP IR was robust and further supported by SNAPSHOT analysis. Division of Acquired Immunodeficiency Syndrome (DAIDS) grade 3 and 4 events were similar for the NVP XR and NVP IR groups (3.7 vs. 4.1%, respectively), although overall AEs were higher in the NVP XR group (75.6 vs. 60.1% for the NVP-IR group). NVP XR administered once daily resulted in continued virological suppression at week 24 that was noninferior to that provided by NVP IR, with similar rates of moderate and severe AEs. The higher frequency of overall AEs with NVP XR may be a consequence of the open-label design.