MBC 78 5.1% 750 mg BD refractory T EGF105084a Ren / relapsed HER �w 2 nd brain metastases 39 2.6% 1500 mg OD EGF103009 chemo / T refractory / recurrent IBC, HER 2 � epigallocatechin 989-51-5 EGFR SA 2141 HER 2 40% b EGFR HER 2: 1 PR EGF100642 1500 mg OD chemotherapy refractory / rer T LABC / MBC, HER 2 � SA February 67 HER 2 24% of HER 2: 5% EGF20008 1500 mg OD chemotherapy refractory ABC / MBC 229 HER 2 4.3%, HER-2: 0.0% EGF20009 C 1500 mg or 500 OD BD Frontline HER 2 � �L ABC / MBC 138% jib 24 mg aan EGF105084 lapatinib 1250 mg OD � apecitabine 2000 mg / m 2 / day is under way, the response rate based on bestimated vorl more often data CBY independent Independent Examination.
Abbreviations: RR, response rate, overall response rate, overall response rate, OD, once t was like, BD, two possible t, T, trastuzumab, chemotherapy, chemotherapy, LABC, MBC locally advanced breast cancer, metastatic breast cancer, IBC infl ammatory breast cancer, FAK pathway PR, partial response, CR complete response. 28 OncoTargets and Corkery et al 2008:1 treatment of CNS relapse. This may be the partly due to the limited F ability of trastuzumab to cross the BBB. EGF20009 in 6 patients were included with CNS disease stabilization. One patient had had a CNS relapse only, 3 patients had systemic relapse only, one patient died of objective assessment, and one remained without relapse at the time of recruitment. In theory, lapatinib has a gr Ere F Ability to cross the BBB, although pharmacokinetic studies have shown that low central nervous system drugs have demonstrated in normal healthy animals.
EGF105084 specifi cally investigates the use of lapatinib monotherapy in brain metastases in breast cancer with HER 2 positive before treatment with trastuzumab. Preferences INDICATIVE results of this phase II study reported an overall response rate of 2.6% of the CNS, 6 patients with stable disease and 7 patients with progression-free survival after 16 weeks. There were four non-CNS-PR. A correlation between tumor volume reduction, and Physicians for neurological signs and symptoms was also observed. A shipping Ngerungsarm to EGF105084 for patients with disease progression has enabled patients to be offered lapatinib 1250 mg per day � apecitabine mg/m2/day 2000th Of the 40 patients enrolled in this arm had 20% 50% reduction in tumor volume, and 40% had a 20% reduction FINISH.
This vorl Ufigen data suggest that the combination of lapatinib and capecitabine to benefit k Can in patients with CNS disease has progressed to be on lapatinib monotherapy. Lapatinib in combination with the chemotherapy combination of an analogue of lapatinib with capecitabine metabolite 5, 5 fl was deoxy uorouridine in vitro synergistic in cell lines of breast cancer. A phase I study found the optimal tolerated regimen for the combination of lapatinib 1250 mg t Possible and capecitabine 2000 mg/m2/day on days 1-14 of a 21-t Pendent cycle. Four responses were reported in 45 patients confidence RMED, including two breast cancer. Complete remission occurred in one patient who had disease progression w During treatment with trastuzumab. An open-label phase III randomized clinical trial on the basis of these encouraging data performed.
A total of 399 patients with locally advanced or metastatic HER-2 positive breast cancer, the confinement after treatment Lich trastuzumab, anthracyclines, was advanced and taxanes were randomized to the combination of lapatinib and capecitabine than capecitabine only. The prime Re endpoint was the time to disease progression. A vorl INDICATIVE analysis was reported in 2006 with 324 patients showed a significant approximately