Twenty two percent of patients (34 patients) presented with overt bleeding. Table 1 Comparison of clinical characteristics among non-ACCESS, pre-ACCESS, and post-ACCESS groups at LHSC Clinical characteristics Non-ACCESS Pre-ACCESS Post-ACCESS P value   Number of patients, n 65 47 37 – Reason for presentation to hospital, n(%):       RG7112 clinical trial 0.98   Change in bowel movements 40 (62) 26 (55) 14 (38)     Rectal Bleeding 15 (23) 12 (26) 7 (19)     Anemia 14 (22) 7 (15) 8 (22)     Obstruction 37 (57) 22 (47) 15 (41)     Pain 49 (75) 33 (70) 23 (62)   Colonoscopy, n(%):       0.02   Prior outpatient AZD1390 in vivo colonoscopy 15 (23) 19 (40) 5 (14)     Inpatient colonoscopy 16 (25)

9 (19) 14 (38)   Indications for colonoscopy, n(%):       0.91   Change in bowel movements 15 (23) 5 (11) 15 (40)     Rectal bleeding 13 (20) 7 (15) 11 (30)     Anemia 14 (22) 6 (13) 7 (19)     Obstruction 9 (14) 4 (8) 11 (30)     Pain 17 (26) 9 (19) 15 (40)   Location of malignancy, n(%):       0.49   Rectal 6 (9) 7 (15) 1 (3)     Sigmoid and rectosigmoid 15 (23) 17 (36) 11 (30)     Descending 6 (9) 4 (8) 3 (8)     Transverse 7 (11) 4 (8) 3 (8)     Ascending 31

(48) 15 (32) 19 (51)   Stage, n(%):       0.15   0/I 3 (5) 5 (11) 4 (11)     II 25 (38) 10 (21) 18 (49)     III 25 (38) 20 (42) 11 (30)     IV 10 (15) 9 (19) 4 (11)     Unknown 2 Cytoskeletal Signaling (3) 4 (8) 0 (0)   P values are shown for comparisons between pre- and post-ACCESS groups. Seventy eight patients (52%) underwent colonoscopy: 31 patients (48%) were in the non-ACCESS group; 28 patients (60%) were in the pre-ACCESS group; and 19 Dapagliflozin patients (51%)

were in the post-ACCESS group (Table 1). There were no statistical differences between the three groups for symptoms necessitating colonoscopy (p = 0.91), location of the malignancy (p = 0.49), or pathological stage (Table 1; p = 0.15). However, we observed a significant difference in the distribution of inpatient and outpatient colonoscopies between the pre- and post-ACCESS groups. In the pre-ACCESS group, 9 patients (19%) had an inpatient colonoscopy while 19 patients (40%) had an outpatient colonoscopy; in contrast, 14 post-ACCESS patients (38%) had an inpatient colonoscopy compared to only 5 patients (14%) who had an outpatient colonoscopy (p = 0.02). We also observed a significant difference between the pre- and post-ACCESS groups with respect to the timing of surgical treatment following inpatient colonoscopy (Table 2). In the pre-ACCESS group, five out of 9 patients undergoing inpatient colonoscopy (56%) were discharged and underwent surgery during a separate admission: three patients were diagnosed with CRC after an admission for rectal bleeding, stabilized with blood transfusions, and underwent elective surgery within a week of being discharged from their initial admission, due to a lack of emergency OR time.