55 vs 1.32 gm per minute in the first 4 vs the last 5 years. Further efficiency improvements were noted in the last 5 years with a mean of 1.57 gm per minute enucleated in the last 2 years.
Conclusions: As experience with holmium laser enucleation of the prostate grows, advances in operative technique have been made. Prostatic enucleation efficiency continues to improve, further strengthening the role of holmium laser enucleation of the prostate for benign prostatic hyperplasia of small and large prostate glands.”
“Numerous
studies have shown that bilateral vestibular deafferentation (BVD) results in spatial memory deficits and hippocampal dysfunction in Selleck MK1775 rats and humans. Since cannabinoid CB1 receptors are well known to regulate synaptic plasticity in the hippocampus, we investigated whether BVD resulted in changes in CB1 receptor expression and affinity in the rat hippocampus at 1,3 and 7 days post-surgery, using a combination of Western blotting and radioligand binding. Using Western blotting, we found that CB1 receptor expression was significantly lower in BVD animals compared to sham controls only in the CA3 area across the 3 time points (P = 0.03). CB1 receptor expression decreased significantly over time for both the BVD and sham
https://www.selleckchem.com/products/a-1331852.html animals (P = 0.000). The radioligand binding assays showed no significant change in the IC50 of the CB1 receptor for the cannabinoid CB1/CB2 receptor agonist, WIN55,212-2. These results suggest that the CB1 receptor Methane monooxygenase down-regulates in the CA3 region of the hippocampus following BVD, but with no changes in the affinity of the CBI receptor for WIN55,212-2. (C) 2010 Elsevier Ireland Ltd. All rights reserved.”
“Purpose: Well done systematic reviews provide the highest quality evidence for clinical questions of therapeutic effectiveness. We assessed the methodological quality of systematic reviews in the urological literature.
Materials and Methods: We systematically investigated all systematic reviews published in 4 major urological journals from 1998 to 2008. Studies were identified
using a predefined search strategy in PubMed(R) and confirmed by a hand search of journal tables of contents. A validated 11-point instrument to assess the methodological quality of systematic reviews was applied by 2 independent reviewers after a pilot testing phase. Disagreements were discussed and resolved by consensus.
Results: The systematic literature search identified 217 individual systematic reviews, of which 57 ultimately met study eligibility criteria. Ten (17.5%), 20 (35.1%) and 27 (47.4%) systematic reviews were published in 1998 to 2001, 2002 to 2005 and 2006 to 2008, respectively. Using the measurement tool to assess systematic reviews the mean +/- SD score was 4.8 +/- 2.0 points. Fewer than half of all systematic reviews performed a systematic literature search that included at least 2 databases (49.1%) or unpublished studies (31.6%), or provided a list of included and excluded studies (45.6%).