Measurements of crystal structure, Curie temperature, magnetization, and magnetostriction were made on TbxPr1-x(Fe0.8Co0.2)(1.9) alloys. X-ray diffraction results show that the alloys exhibit C15 cubic Laves phase with MgCu2-type structure. The lattice parameter decreases with increasing Tb concentration, while the Curie temperature increases. Because of the antiparallel magnetic moment of Tb and Pr, the saturation magnetization decreases with increasing Tb concentration. The magnetostriction
of TbxPr1-x(Fe0.8Co0.2)(1.9) shows a peak at low magnetic fields, while Navitoclax manufacturer that of TbxPr1-x(Fe0.8Co0.2)(1.9) exhibits a minimum in the whole range of magnetic fields. (C) 2009 American Institute of Physics. [DOI: 10.1063/1.3073849]“
“Objective: AZD0530 Describe the main activation and inhibitory pathways and receptors by which pDC regulate type I interferon secretion, as well as its association with autoimmune pathology.
Methods: A PubMed search for articles was conducted using the following key words: plasmacytoid dendritic cells, autoimmune diseases, viral infections and type I interferon. The search was limited to publications in English
and from 1957 to 2012. Sixty-five of these articles are included in this review. The most relevant primary research articles identified were critically evaluated and compiled together. Particularly, areas of consensus and controversy were identified and analyzed.
Results: Plasmacytoid dendritic cells have been closely related to viral infections and autoimmune disease, mainly because of these immune cells are able to secrete large amounts of type I interferon. This function is linked with their expression of Toll-like receptors, specially TLR7 and TLR9, which are designed to sense nucleic acids in the early endosomes. Activated pDC can promote immunity and autoimmunity, however, the exact mechanisms by which pDC promote
one vs. the other are not well understood.
Conclusions: Plasmacytoid dendritic cells play a key role in both, immunity and autoimmunity. Current evidence suggests that the sustained overproduction of type-I interferon drives aberrant immune responses and the development of autoimmune pathology. (C) 2013 Elsevier Inc. All rights reserved.”
“Background: Lymph node status in EC determines INCB028050 price the staging and has important prognostic and therapeutic implications.
Objectives: We have examined the diagnostic value of preoperative and intraoperative non-invasive methods to determine the lymph node status in endometrial cancer, or, indirectly, for identification of patients at increased risk of lymph node involvement.
Search strategy: We conducted a literature search to identify all relevant reports that evaluated lymph node spread in EC.
Selection criteria: Articles were only considered when data of investigational modalities were compared with histopathological findings of the surgical specimens, considered as the gold standard.