0) 20 (87.0) 18 (78.3) Female 18 14 (77.8) 16 (88.9) 11 (61.1) Age

        ≤60 years 33 27 (81.8) 29 (87.9) 25 (75.8) >60 years 8 7 (87.5) 7 (87.9) 4 (50) Tumor size         ≤3 cm 16 12 (75.0) 12 (75.0) * 13 (81.3) >3 cm 25 22 (88.0) 24 (96.0) * 16 (64) Clinical Stage         Stage I-II 24 18 (75.0) * 19 (79.2) * 20 (83.3) * Stage III-IV 17 17 #Dorsomorphin randurls[1|1|,|CHEM1|]# (100.0) * 17 (100.0) * 9 (52.9) * B symptom         No 16 13 (81.3) 13 (81.3) 11 (68.8) Yes 25 21 (84.0) 23 (92.0) 18 (72) Location         Single location 14 9 (64.3) * 10 (71.4) * 12 (85.7) * Multiple location 27 25 (92.6) * 26 (96.3) * 17 (63) * * P < 0.05 (2) The MMP-9 expression ratio in the multiple locations group (96.3%) was higher than that in the single location group (71.4%), in the clinical stage III-IV group (100%) than that in the clinical stage I-II group (79.2%), and in the >3 cm tumor size group that in the ≤3 cm group (96% vs. MMP-9 expression ratio showed no signification difference in gender and age. The highly positive correlations of MMP-9 expression ratio with multiple location dissemination, higher UICC stages and larger tumor size were observed. (Table 2); (3) Contrary to CCR7 and MMP-9, MMP-2 showed higher expression in single

location group compared with multiple locations group (52.9% vs. 83.3%, P < 0.05). MMP-2 expression was also significantly associated with lower UIUC stages (83.3% vs 52.9%). (4) Other clinical parameters without statistical significance were not included in the table. Correlation among all indices in T-NHL The high see more expression of CCR7, MMP-9, and MMP-2 in T-NHL was analyzed with Spearman’s correlation analysis. The relationship between CCR7 and MMP-9 (rs = 0.395, P < 0.05) expressed direct correlation. The relationship among other markers showed no significant correlation (P > 0.05). Transwell invasion experiment result (Table 3) Table 3 Cellular count in the lower chamber in Transwell invasion experiment ( ± s, n = 9)   Control group S50 group S100 group S200 group Jurkat 10.63 ± 5.52 20.70 ± 8.40✩ 33.43 ± 10.61✩ 49.13 ± 21.01✩ Hut 78 15.00 ± 6.48⋆ 35.37 ± 18.21⋆▴ 42.26 ± 20.17▴ 72.60 ± 34.12⋆▵ ⋆Compared with corresponding

group of Jurkat cells, P < 0.01; ✩Compared with the other groups of Jurkat cells (including the control group), P < 0.01; ▴Compared with the control group and of S200 group of Hut 78 cells, Coproporphyrinogen III oxidase P < 0.01; ▵Compared with the other groups of Hut 78 cells (including the control group), P < 0.01. In the lower chamber, there were more Hut 78 cells than Jurkat cells in all groups except S100 group (P < 0.01). The number of Hut 78 and Jurkat cells that penetrated the membrane in the S50, S100, and S200 groups were all higher than that in the control group (P < 0.01). For the Hut 78 cell line, the cells in the S200 group were higher than that in the S50 group, whereas for the Jurkat cell line, the cells in the S100 group were higher than that in S50 group, and the cells in S200 were higher than that in S100 group (P < 0.01).