0%, 34.2%, and 45.0%, respectively. While 45 patients had complete virologic response to antiviral therapy at 6 months after resection, 27 patients had incomplete virologic response. A multivariable analysis showed that risk factors for recurrence were the multi-nodularity (hazard ratio (HR) 8.27, p = 0.001), presence of microvascular invasion (HR 2.92, p = 0.006), and incomplete virologic response to anti-viral therapy (HR 2.98, p = 0.009). Conclusion: Virologic Wnt inhibitor response to antiviral therapy was associated with the recurrence

of after curative resection in patients with HBV-related HCC. This study suggests that active suppression of hepatitis B viral load can prevent the recurrence of HCC after resection. Ibrutinib concentration Key Word(s): 1. hepatitis B; 2. hepatocellular carcinoma; 3. antiviral therapy Presenting Author: SUBASIN KATTADIGE CHAMILA ERANDAKA SUBASINGHE Additional Authors: YASHODA NANDAMUNI, SAMEERA RANASINGHE, KULEESHA KODISINGHE, MADUNIL ANUK NIRIELLA, ARJUNA DE SILVA, JANAKA DE SILVA Corresponding Author: SUBASIN KATTADIGE CHAMILA ERANDAKA SUBASINGHE Affiliations: North Colombo Teaching Hospital, North Colombo Teaching Hospital, North Colombo Teaching Hospital, North Colombo Teaching Hospital, North Colombo Teaching Hospital, North Colombo Teaching Hospital Objective: Minimal hepatic encephalopathy (MHE) has

no recognizable clinical symptoms of hepatic encephalopathy (HE) but has mild cognitive and psychomotor deficits which can interfere with executive decision making and psychomotor speed. It affects driving ability and previous studies in Western countries have demonstrated an association between MHE and increased road accidents. Our objective was to investigate this association in a cohort of Sri Lankan cirrhotic drivers. Methods: A prospective, case controlled study ongoing study has been conducted in the Gastroenterology Clinic, University Medical

Unit, North Colombo Teaching Hospital, Ragama, from August 2013. Patients with cirrhosis of any aetiology, without overt HE, who had been driving any vehicle during the past one month were subjected to 5 standard pencil-paper based psychometric tests used to detect MHE. Road accidents were recorded for both cirrhotic drivers with MHE and controls. Accidents were categorized as major when they resulted in hospitalization of the involved MCE公司 person/s, and minor when there were no serious injuries. Results: Among 55 cirrhotic drivers with MHE [males, median age 53 years (range 30-60)], 7 (12.7%) reported any type of accident compared to 6 (10.9%) among 55 controls [males; median age 51 years (range 30-60)]. 2/55 (3.6%) cases and 2/55 (3.6%) controls reported minor accidents. There were no major accidents in either group. Conclusion: Preliminary results of this ongoing study do not indicate an increased frequency of road accidents in a cohort of Sri Lankan cirrhotic drivers with MHE. Key Word(s): 1. minimal hepatic encephalopathy; 2. road accidents; 3.