1 26.2 23.0 1.0 2.1 4.0 1.2 1.0 3 1 7 0 NQM1 Transaldolase Semaxanib in vitro of unknown function 1.1 0.8 10.2 3.4 6.1 1.0 1.2 1.1 0.6 0.6 3 1 2 0 TKL1* Transketolase 1 1.6 0.2 0.6 1.0 0.6 1.0 0.2 0.8 0.3 0.1 1 1 2 0 TKL2 Transketolase 2 0.9 0.8 1.3 0.7 1.1 1.0 1.0 0.5 0.5 0.5 2 2 1 0 PRS1* 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase 2.2 0.3 0.5 1.0 0.9 1.0 0.3 1.1 0.4 0.3 0 2 6 0 PDR family PDR1* zinc finger transcription factor for pleiotropic drug response 1.7 0.9 1.0 0.9 1.0 1.0 0.7 1.0 0.4 0.3 0 1 0 0 PDR5* Plasma membrane ATP-binding cassette (ABC) transporter 4.4 0.5 0.4 0.3 0.4 1.0 0.2 0.6 0.3 0.1 1 2 6 8 PDR12* Plasma membrane ATP-binding cassette (ABC) transporter 1.5 1.3 0.7 0.7 0.9 1.0 1.0 0.6 0.3 0.2 0 1 2

0 PDR15 ATP binding cassette (ABC) transporter of the plasma membrane 1.3 1.7 1.5 2.3 1.7 1.0 1.0 0.9 0.4 0.3 5 0 0 3 YOR1* ATP binding cassette (ABC) transporter of the plasma membrane 2.2 0.8 0.8 0.5 0.4 1.0 0.6 0.9 0.1 0.1 2 1 0 2 SNQ2* ATP binding cassette (ABC) transporter of the plasma membrane 2.3 0.6 0.4 0.7 0.5 1.0 0.3 0.5 0.2 0.1 1 2 0 7 ICT1* Lysophosphatidic acid acyltransferase 2.0 0.6 0.6 0.4 0.6 1.0 1.0 1.2 0.7 0.4 1 0 2 2 DDI1* DNA damage-inducible v-SNARE binding protein 1.7 1.7 2.0 1.7 2.4 1.0 1.1 2.0 1.0 0.6 1 1 0 0 TPO1* Vacuolar polyamine-H+ antiporter 1.7 1.0 2.0 3.1 3.5 1.0 1.4 2.6 1.9 1.0 2 3 0 2 GRE2* Methylglyoxal reductase (NADPH-dependent)

4.1 1.4 1.5 1.6 1.8 1.0 1.3 1.5 0.6 0.5 0 1 2 2 YMR102C* Protein of unknown function 1.6 1.2 1.1 1.2 1.0 1.0 1.2 0.9 0.7 0.6 1 0 0 3 Fatty acid metabolism ETR1 Mitochondrial Mizoribine mw respiratory function protein 0.9 1.0 1.5 2.1 1.7 1.0 1.6 1.3 0.7 0.5 2 2 2 0 ELO1* Elongase I, Fatty acid elongation protein 1.6 0.8 1.3 1.8 1.0 1.0 0.5 0.7 0.4 0.3 0

1 2 0 HTD2 Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis 1.1 0.9 1.1 1.1 1.0 1.0 0.7 1.1 0.5 0.5 0 0 0 0 Egosterol biosynthesis ERG4* C-24(28) sterol reductase 1.5 0.5 0.6 0.5 0.3 1.0 0.7 0.4 0.2 0.2 0 0 2 2 ERG20 Farnesyl-pyrophosphate synthetase 0.9 0.7 0.9 Edoxaban 0.9 0.6 1.0 0.6 1.3 0.6 0.4 1 1 0 0 ERG26 C-3 sterol dehydrogenase 1.0 0.4 0.9 0.8 0.8 1.0 0.4 0.8 0.5 0.4 0 1 5 0 SIS 3 Proline metabolism PUT1 Proline oxidase 0.6 0.8 2.7 1.8 4.9 1.0 5.1 3.8 6.0 2.6 0 0 0 0 PRO1* Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis 1.6 1.0 0.7 0.9 0.7 1.0 0.7 1.0 0.5 0.3 0 0 2 0 Tryptophan biosynthesis TRP5* Tryptophan synthase 1.5 0.5 1.0 1.4 0.7 1.0 0.4 1.3 0.5 0.2 4 2 0 0 Glycerol metabolism DAK1 Dihydroxyacetone kinase 1.2 2.2 2.0 1.9 1.8 1.0 1.6 2.0 0.7 0.3 0 0 0 0 GCY1 Putative NADP(+) coupled glycerol dehydrogenase 1.1 0.9 4.3 5.4 4.8 1.0 1.1 4.1 2.2 1.7 1 1 2 0 GPD1 NAD-dependent glycerol-3-phosphate dehydrogenase 1.3 0.8 1.0 1.1 0.5 1.0 1.4 1.0 0.3 0.2 4 1 0 0 GUP1 Multimembrane-spanning protein essential for proton symport of glycerol 1.2 1.0 0.9 1.2 0.8 1.0 0.6 1.0 0.5 0.3 0 0 0 0 GUP2* Putative glycerol transporter involved in active glycerol uptake 1.8 0.8 0.6 1.0 0.6 1.0 0.7 1.0 0.6 0.