of phIn its N-terminal region. Weiterf. Promotion of physiological substrate such as oxidized glutathione 2-Methoxyestradiol or LTC4, ABCC1 may bear anti-cancer agents such as anthracyclines and mitoxantrone, as well as drugs glutathione conjugates, sulfate or glucuronate Tr a hunter of drugs most recently identified ABCG2, as ABCP resistance protein in breast cancer or mitoxantrone resistance protein, which has a carrier consisting hunter with half NBD and TMD from six transmembrane helices is known. Unlike ABCB1 and ABCC1, ABCG2 must dimerize to function, and it is to function as a homodimer or oligomer Similar ABCB1 and ABCC1, ABCG2 transports a variety of drugs, including normal anthracyclines, mitoxantrone, topotecan, etoposide, prazosin, and flavopiridol and other compounds such as riboflavin and sterols.
ABCG2 expressed on stem cell lines in normal and cancer cells. Cancer treatment clinical significance often involves the use of chemotherapeutic agents, but these drugs are not always effective. This Dovitinib loss of efficiency is mainly with the overexpression of ABC transporters of drugs for the first time in the early 1970s, was described s correlated. Various tumors including renal cell carcinoma cortex, the c Lon and hepatocellular Ren carcinomas express ABCB1 and are Haupt Chlich chemoresistance. In contrast to this, exposure to chemotherapeutic agents upregulation of ABC transporters at the recurrence of the disease in cancers with low basal expression of this transporter. Expression of ABC transporters in patients with Leuk mie, Myeloid leukemia Documented chemistry With acute 30 patients express ABCB1 and more than 50 express ABCB1 relapse.
Plasschaert and colleagues showed that ABCG2 expression was h Ago and is functionally active acute leukemia Mie Line B lymphoblastic cell line samples in T. In its report, the wild-type ABCG2 gene was found in samples transported rhodamine 123. Although expression of the ABCB1 plays an r In MDR leukemia Mie Important differences exist in the studies to assess the importance ABCG2 in this type of cancer. ABCG2 expression has been reported in a variety of cancers and other is the largest human-run in the c Lon, stomach and feeding hre. Zus to Tzlich multidrug resistance ABC transporter cause have a great impact on the pharmacokinetics of chemotherapeutic agents. ABCB1 and ABCG2 expressed both at the blood-brain barrier and in the gastrointestinal tract.
Expression of ABC transporters in these biological barriers to absorption of various compounds in these tissues. The oral bioavailability of a number of anti-cancer agents is ver by expression of the ABC transporter ABCG2 Nozzles changed was also in the apical membrane of alveolar epithelial cells in lactating mammary gland of M, Cows and humans have been identified, and it is used to drug transfer and xenotoxins in breast milk. Although ABCG2 plays an r Protector of the mammary gland, paradoxically, carcinogens and toxins A