4–6 In addition, the three antimalarials are characterized by very different dosing regimens: At+Pro and Dxy are taken on a daily basis before, during, and after traveling, whereas Mfl is taken weekly; At+Pro and Dxy must be taken 1 to 2 days prior to travel, compared with at least 1 week (preferably 2–3 wk) for Mfl; and after return Dxy and Mfl must be taken for 4 weeks post-travel, compared with 1 week for At+Pro.7 These variations in side-effect profile and dosing convenience may impact the adherence

behavior of travelers taking these medications. Other factors such as travelers’ beliefs about malaria and antimalarial medication and previous experience of taking antimalarials may also be important. Data Paclitaxel price on the impact of travelers’ beliefs or choice of antimalarial on adherence behavior are limited, especially in the UK, and no studies have compared At+Pro with Dxy.5,8–10 There is, therefore, a need for further research to provide HCPs with the information they need if they are to promote adherence to antimalarial medication. This observational study examines two areas related to antimalarial use: the adherence behavior of travelers from the UK to crPF malarious zones, who were prescribed a recommended antimalarial (primary objective),

and the factors influencing selection of the antimalarial from the perspective of the prescriber and traveler. The results of this study should better equip HCPs to provide information and advice to travelers when prescribing antimalarials. This study was a noninterventional, observational study conducted in travel clinics in England and Scotland Bioactive Compound Library cell assay between December 2004 and April 2006, to assess the adherence behavior of individuals prescribed a licensed antimalarial at a travel clinic for a trip to a crPF malarious zone. Eleven clinics participated from London, Manchester, Glasgow, Cambridge, Bristol, and Edinburgh: six Medical Advisory Services for Travelers Abroad (MASTA) travel clinics, four Nomad travel clinics and the Royal Free Hospital travel clinic. The study was approved by Cambridge Local Research Farnesyltransferase Ethics

Committee and informed consent was obtained from all participants. The investigators in this study were mostly nurse practitioners responsible for the selection and supply of antimalarials under a system of patient group directions (PGD).11 All individuals having a naturally occurring consultation with a participating practitioner requesting antimalarial protection for travel to crPF malarious zones were considered for participation in the study once a decision to prescribe an antimalarial had been made as per routine practice. Treatment choice was solely at the discretion of the traveler and practitioner. To be eligible, travelers had to be at least 18 years of age and to have been prescribed or supplied under PGD an antimalarial medication as a result of planned travel for a duration of 28 days or less.