5, and 3 mph), and biking, respectively. Biking was the only activity with significant differences in EE estimations (P < 0.001). Average minute-by-minute correlations across individuals was r = 0.71
+/- 1.3 indicating that the relationships were consistent across individuals. Conclusions: The newly developed algorithms demonstrate improved accuracy for assessing EE for typical activities in children-including accurate estimation of light activities.”
“Alzheimer’s disease (AD) involves progressive accumulation of amyloid beta-peptide (A beta) and neurofibrillary pathologies, and glucose hypometabolism in brain regions critical for memory. The 3xTgAD mouse model was used to test the hypothesis that a ketone esterebased diet can ameliorate AD pathogenesis. Beginning at a presymptomatic age, 2 groups of male 3xTgAD mice were fed a diet containing a physiological
enantiomeric precursor of ketone bodies (KET) or an isocaloric carbohydrate BIIB057 diet. The results of behavioral tests performed at 4 and 7 months after diet initiation Dinaciclib mouse revealed that KET-fed mice exhibited significantly less anxiety in 2 different tests. 3xTgAD mice on the KET diet also exhibited significant, albeit relatively subtle, improvements in performance on learning and memory tests. Immunohistochemical analyses revealed that KET-fed mice exhibited decreased A beta deposition in the subiculum, CA1 and CA3 regions of the hippocampus, and the amygdala. KET-fed mice exhibited reduced levels of hyperphosphorylated tau deposition in the
same regions of the hippocampus, amygdala, and cortex. Thus, a novel ketone ester can ameliorate proteopathic and behavioral deficits in a mouse AD model. Published by Elsevier Inc.”
“Specification of endoderm is the prerequisite for gut formation in the embryogenesis of bilaterian organisms. Modern lineage labelling studies(1-3) have shown that in the sea urchin embryo model system, descendants of the veg1 and veg2 cell lineages produce the endoderm, and that the veg2 lineage also gives rise to mesodermal cell types. It is known that Wnt/beta-catenin signalling is required for endoderm specification(4-6) and Delta/Notch signalling is required for mesoderm specification(7-9). Some directcis-regulatory targets of these signals have been found(10,11) and various phenomenological patterns of gene expression have been observed in MK-4827 order the pre-gastrular endomesoderm. However, no comprehensive, causal explanation of endoderm specification has been conceived for sea urchins, nor for any other deuterostome. Here we propose a model, on the basis of the underlying genomic control system, that provides such an explanation, built at several levels of biological organization. The hardwired core of the control system consists of the cis-regulatory apparatus of endodermal regulatory genes, which determine the relationship between the inputs to which these genes are exposed and their outputs.