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“Background Physical activity leads to increased metabolic rate and heat production [1], resulting in loss of water and electrolytes and glycogen depletion in the liver and muscles [1, 2]. The loss of these elements may lead to dehydration, affecting physical performance and impairing health [3]. Fluid replacement using isotonic solution may attenuate or prevent many metabolic, cardiovascular, thermoregulatory and performance perturbations [4, 5]. Moreover, according to Brouns et al., [6] and Coyle [7], Small molecule library screening sports drinks without caffeine can help to maintain physiological homeostasis. Another aspect of risk related to exercise is failure

of cardiovascular function, especially for practitioners who exercise infrequently [8]. It is known selleck chemicals that reduced cardiac parasympathetic regulation associated with increased sympathetic activation may trigger malignant ventricular arrhythmias, and that systemic metabolic disorders (electrolyte imbalance, hypoxia), as well as hemodynamic or neurophysiological (fluctuations in the activity of the autonomic nervous system) disorders appear to play an important role in lethal arrhythmias [9]. In addition, the physiological overload imposed on the body is enhanced when exercise is associated with dehydration. According to Carter et al., [5], “the combination of these two factors suggests changes in the global cardiac autonomic stability”. In combination with dehydration, exercise has been shown to cause post-exercise alterations in the baroreflex control of blood pressure [10]. Charkoudian et al., [10] demonstrated that even modest hypohydration (1.6% of body weight) can blunt baroreceptor control of blood pressure and that physiological responses were not

observed following an intravenous infusion of saline to restore the plasma volume after exercise in the heat. Although it is known that changes in the cardiovascular system are caused by hydration during and after exercise, GNA12 few studies have evaluated the influence of hydration on the autonomic nervous system (ANS) and none have evaluated this influence when isotonic drink is also administered during and after prolonged exercise. Our purpose, therefore, was to evaluate the effects of hydration protocols on autonomic modulation of the heart in young people during and post-exercise. We hypothesized that hydration during exercise and recovery may attenuate autonomic changes induced by exercise and accelerate recovery.