All patients were principally treated according to the strategy o

All patients were principally treated according to the strategy of the Surviving Sepsis Campaign Guidelines [8].Data collectionPatients were followed until 28 days after entry into the study. The variables considered selleck chemical JQ1 to assess comparability among the two groups were age, sex, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Sequential Organ Failure Assessment (SOFA) score, number of dysfunctional organs, site of infection and rate of positive blood culture.We evaluated 28-day mortality and physiological and biochemical variables. Platelet counts and the levels of C-reactive protein (CRP) and fibrinogen degradation products (FDP) on sequential days were assessed. SOFA score was recorded on days 0, 1, 2, 3, 7, 14 and 28. The presence of serious adverse events related to bleeding was recorded.

Serious bleeding events were defined as follows: fatal bleeding (overt bleeds considered the primary cause of death), nonfatal serious bleeding (defined as intracranial hemorrhage confirmed by brain imaging, gastrointestinal or respiratory tract bleeding uncontrollable by conservative treatments, and bleeding at a critical location such as retinal hemorrhage, major hemarthrosis or spinal hemorrhage) or any life-threatening bleeding that led to discontinuation of the administered study drug.Statistical analysisData are expressed as group means �� standard error of the mean, medians with interquartile ranges, or percentages as appropriate. Continuous variables were compared between groups by using Student’s t-test or nonparametric test as appropriate.

Categorical variables were analyzed by using the ��2 test or Fisher’s exact test as appropriate. Univariate analysis of time to mortality was compared by using a log-rank test. In addition, stepwise multivariate Cox regression analysis was used to assess the covariates that were associated with time to mortality. Adjusted curves of time to mortality by associated covariates were estimated.The comparisons of SOFA scores, platelet counts and CRP and FDP levels between groups over time were analyzed by repeated measures analysis of variance (ANOVA) adjusted for the baseline values as a covariate and by post hoc Bonferroni test. In addition, the last-observation-carried-forward (LOCF) method [16] for missing data was used for the analysis. Missing samples occurred because of death, discharge from hospitals and samples not drawn.

A P value < 0.05 was considered statistically significant. Statistical analyses were performed using SPSS for Windows version 17.0 software (SPSS, Inc., Chicago, IL, USA).ResultsBaseline characteristicsTwenty patients were treated with rhTM (rhTM group), and 45 patients were treated without rhTM (control group). The baseline characteristics of the study population are shown in Table GSK-3 Table1.1.

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