Br J Cancer 2007, 97:927–933.PubMed 25. Gullo C, Au M, Feng G, Teoh G: The biology of Ku and its potential oncogenic role in cancer. Bba-Rev Cancer 2006, 1765:223–234. 26. Johnstone RW, Ruefli AA, Lowe SW: Apoptosis: a link between cancer genetics and chemotherapy. Cell 2002, 108:153–164.PubMedCrossRef 27. Siddik ZH: Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003, 22:7265–7279.PubMedCrossRef 28. Soldani C, AZD1208 mouse Scovassi AI: Poly(ADP-ribose) polymerase-1 cleavage during apoptosis: an update. Apoptosis 2002, 7:321–328.PubMedCrossRef 29. Li G, Nelsen C,

Hendrickson EA: Ku86 is essential in human somatic cells. Proc Natl Acad Sci USA 2002, 99:832–837.PubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions QM and PL performed all the experiments and drafted the manuscript. MX and JY collected and provided the tissues. ZS and WL have contributed the data collection and interpretation. JZ oversaw the design of the study, was involved in the critically revised manuscript. All authors have read and approved the final version of the manuscript.”
“Introduction Despite the decline in its incidence in the past few decades, gastric cancer

remains the second and fourth leading cause of cancer-related death in men and women respectively [1]. Patients with gastric Tanespimycin order cancer have excellent survival if there is no regional lymph node involvement [2]. Unfortunately, gastric cancer is difficult to be diagnosed at an early stage. As a result, there is great interest in finding a prognostic marker for this potentially curable group of patients. The transcription factor Cdx2 is a member of the caudal-related homeobox gene family, which plays an important 17-DMAG (Alvespimycin) HCl role in the proliferation and differentiation of intestinal epithelial cells, and is involved in the development and progression of gastric cancer [3, 4]. A number of reports suggest that Cdx2 expression

is a characteristic feature of human gastric cancer and served as a potential biomarker of tumor progression in early gastric carcinoma [5–8]. However, the relation between Cdx2 expression and clinicopathological features remains controversial. So far several studies have demonstrated that Cdx2-positive expression in gastric cancer was significantly correlated with better differentiation and lower rate of lymph node metastasis [9–11]. However, Xiao and colleagues showed that there was not association between Cdx2 expression and lymph node metastasis of gastric carcinoma [12]. The limited availability of samples might result in variations in the clinical significance of the results.