(C) 2010 Wiley Periodicals,

Inc. J Appl Polym Sci 117: 1047-1054, 2010″
“Anatomopathologic studies have failed to define the fetal inflammatory response syndrome (FIRS) as a cause of fetal death. Here, liver fragments of perinatal autopsies were collected at a university hospital from 1990 to 2009 and classified according to the cause of death, perinatal stress, and gestational age (GA) of the fetus. IL-6, TNF-alpha, and C-reactive protein (CRP) expression were immunostained, respectively, with primary antibody. Cases with congenital malformation, ascending infection, www.selleckchem.com/products/gsk1838705a.html and perinatal anoxia showed increased IL-6, CRP, and TNF-alpha, respectively. Prematures presented higher expression of IL-6 whereas term births showed higher expression of CRP. Cases classified as acute stress presented higher expression of IL-6 and TNF-alpha and cases with chronic stress presented higher expression of CRP. GA correlated negatively with IL-6 and positively with CRP and TNF-alpha. Body weight correlated negatively with IL-6 and positively with CRP and TNF-alpha. Despite the diagnosis of FIRS being clinical and based on serum parameters, the findings in the current SB202190 supplier study allow

the inference of FIRS diagnosis in the autopsied infants, based on an in situ liver analysis of these markers.”
“Hydrophobic drugs are often formulated with hydrophilic polymers to form miscible blends called amorphous solid dispersions. The interaction of moisture with these blends is an important topic, both from stability as well as processing perspectives. In this study, the moisture sorption profiles

of four different drug polymer blends, [felodipine-poly(vinylpyrrolidone) (PVP), indomethacin PVP, felodipine-hypromellose (HPMC), and felodipine-hypromellose acetate succinate (HPMCAS)] were experimentally determined at 25 degrees C, and analyzed using various mathematical models. It was found that the moisture sorption profiles of the drug polymer blends could not be reconstructed using the weight-averaged sum of the moisture sorbed by each of the components. Application of the Flory-Huggins model for ternary systems to extract drug polymer interaction parameter (chi(23)) values using known values ZD1839 datasheet of water drug and water polymer interaction parameters led to ambiguous conclusions about the systems’ thermodynamics. chi(23) values extracted for felodipine-PVP and indomethacin-PVP using this model ranged from -9.6 to 26.9 and -20.4 to 22.0, respectively. It is thought that the presence of specific drug-polymer interactions changed the water drug and the water-polymer interactions in the system. Combined with the mathematically small contribution from the term encompassing chi(23) to the predicted amount of moisture sorbed by the drug-polymer blends, it was concluded that this method cannot be used to unambiguously determine drug polymer interaction parameters in solid dispersions.