Case report A 30 year old, nulliparous woman came to our attention for the occasional selleckchem Dasatinib detection at breast self-examination of a swelling in the lower quadrants of the left breast. Family history was negative for breast cancer, as well as personal history (no comorbidities or hormonal therapy). The examination confirmed the presence of the lesion with hard-elastic consistency and margins defined. Ultrasound showed an ovalar, 5.5cm, well capsulated, hypoechogenic lesion with small fluid areas and without suspicious axillary lymph nodes (Fig. 1). Figure 1 Ultrasound. The lesion is well-capsulated. The lesion was resected. The postoperative course was uneventuful. Histologically the lesion appeared with smooth surface and gray-yellow at the cut.

Microscopic examination showed a fibrous capsule, normal breast parenchyma with marked stromal fibrosis, cystic dilatation of the ducts, apocrine metaplasia, sclerosing adenosis and typical ductal hyperplasia. The histological findings are indicative of a benign lesion with features of hamartoma (Fig. 2). Figure 2 Microscopic examination (H&E, x40). Adipose (A), glandular (G) and fibrous (F) tissue. Six months after surgery ultrasound follow up is negative for recurrence. Discussion and conclusion More often the diagnosis of hamartoma is incidental in women older than 40 years starting mammography screening. Ultrasounds and mammogram show a well-capsulated nodule without calcifications. Imaging features may be similar to those of fibroadenoma (5, 7�C13). The definitive diagnosis is only histological (8, 14, 15).

Very rarely the hamartoma can turn into malignant tumor; few cases of breast invasive ductal carcinoma from hamartoma are described in literature (16, 17), but the correlation is unproved. However, the resection of the hamartoma of the breast is always recommended (8, 14).
Parathyroid carcinoma is a rare cancer. The first known case, described by De Quervain in 1909, was a non-functional tumor whose malignancy was only revealed by the lesion��s macroscopic features. In 1929 Wilder described a case in a patient with primary hyperparathyroidism admitted to the Mayo Clinic. In 1938 Armstrong reported another case of metastatic parathyroid carcinoma associated with primary hyperparathyroidism. This cancer is responsible for 0.4�C5.2% of cases of primary hyperparathyroidism.

The 45�C55 year age group is the most affected, with a slight Brefeldin_A predominance of cases in women (1). A case that came to our attention – the first in over 2500 total thyroidectomies and 40 parathyroid operations – prompted this paper and literature review to establish the current indications for the diagnosis and treatment of this rare disease. Case report The patient was a 35-year-old man with a family history of cancer. He was diagnosed with schizophrenia in 1990 and was under treatment with neuroleptic drugs.