In our own analysis of TNBC treatment at UCLA, we found that factors such as the treatment of lumpectomy, rad Emitting ends and negative operating Cyclopamine 11-deoxojervine margins were associated with significantly better disease-free survival in women with TNBC free. Although the LRR rate k Nnte h Time ago, and the recurrence rate can be shorter in TNBC patients, we believe that lumpectomy with postoperative adjuvant radiotherapy is an excellent topical treatment for many with the disease subtype, and we focused on the cleanliness surgical margins, only the type of surgery Selected hlt. Mechanisms of therapeutic agents in chemotherapy TNBC Although new targeted biological therapies promise in many other subtypes of breast cancer occur, the chemotherapy is the only Behandlungsm Possibility for patients with TNBC. TNBC, s sensitivity and better response to chemotherapy has been well documented, and although doxorubicin and taxanes are joint decisions, the most effective chemotherapy is not clearly clarified Rt.
Current interest on several classes of chemotherapeutic agents, their mechanisms of action focused specifically unique molecular defects TNBC. Platinum salts is well established that TNBC h More common in Vorinostat BRCA mutation carrier hunter and BRCA is. Cancers these women often have a defect in DNA repair recombinant counterpart, which prevents the repair of DNA double-strand breaks. A Similar St Tion was also observed in sporadic TNBC. It is believed that the DNA beautiful digende agent such as platinum, which bind directly to DNA and to perform cross-connection k Can cause irreversible collapse of DNA repair and maintain the regular E treatment outcome. Expression of proteins in S.
about TNBC patients expressed k Nnte an m Gliches biomarkers indicative of the sensitivity of the tumor platinum. Antitubulin of anti-tubulin agents in non-taxane and taxane drugs can be divided. Both works thanks to the stabilization of microtubules, which block on the spindle, the metaphase anaphase transition them and ultimately lead to cell cycle arrest and apoptosis. Ixabepilone, was a semi-synthetic antineoplastic agent derived from natural con epithilones U have a low sensibility t For the mechanisms. For resistance under a theoretical advantage over taxanes bypass efflux pumps and beta-tubulin binding in a manner different from the taxane Ixabepilone sensitivity correlated with tumor expression of high beta-tubulin III, and inversely proportional to the expression of Notf cases Related.
Both ixabepilone and eribulin new taxane not microtubule inhibitors dynamically, even a r Important in the treatment of metastatic disease, especially in patients with anthracycline-taxane-resistant metastatic disease poly adenosine diphosphate ribose polymerase targeted therapy agents of this class are a promising therapeutic target for TNBC. PARP is an enzyme, either single-or double- Recruited-dependent breaks in DNA base excision repair. His Zinkfingerdom Ne binds and cleaves NAD SSB which the setting of a plurality of units of ADP-ribose and unwinding of DNA Sch to be repaired. by the reduction of NAD Tumor necrosis is h beraktivit frequently in tumors with PARP T as a base, such as TNBC breast cancer observed.