Definition and development of HIRREM Through serendipity, one of the authors of this article (L. Gerdes) found that near real time reflection of neural oscillatory activity back to the brain through the medium of audible sound appeared to facilitate a state of relaxation wherein the brain, itself, would tend to change Inhibitors,research,lifescience,medical its own activity patterns toward greater hemispheric EEG symmetry and more optimized proportionation of regional spectral EEG power. We thus described the process facilitated as one of relaxation and auto-calibration

for neural oscillations. The methodology has been continuously refined since its development in 2000–2002, and since 2010, it has been described technically as high-resolution, relational, resonance-based electroencephalic mirroring or HIRREM. The technology is based on provision of auditory musical tones corresponding to dominant frequencies Inhibitors,research,lifescience,medical detectable in individual spectral EEGs, to permit resonance between neural oscillatory Inhibitors,research,lifescience,medical frequencies and auditory tones. It requires no direct energetic input to the brain, no cognitive guidance or education from a clinician, nor any referencing against population norms for the

EEG. Allostatic regulation of neural oscillations through HIRREM Because of the variety of conditions, including “somatic,” that have been reported to benefit from HIRREM on an anecdotal basis (see Overview section), we infer that HIRREM facilitates self-guided and healthful reorganization of neural oscillations at some level(s) of primary neural process, with consequences for both neuropsychiatric health and downstream peripheral Inhibitors,research,lifescience,medical physiology. To model the larger theoretical role of HIRREM, we adduce the concept of allostasis as defined by Sterling (2004, 2012). Allostasis refers

to stability (stasis) through change (allo). Allostasis Inhibitors,research,lifescience,medical highlights the centrality of the brain as the master control center for human physiology, whose primary function is to serve as an instrument for optimal predictive regulation. The concept of allostasis may be clarified through comparison with the more commonly used biomedical concept of homeostasis. Homeostasis as a model of physiological regulation through maintenance Thiamine-diphosphate kinase of predetermined and normative set points Homeostasis Vorinostat solubility dmso refers to stability (stasis) through constancy (homeo) and is a model of physiological regulation in which various systems are described in terms of their requirement to maintain various set points at constant values. These values are deemed normative, and systematic deviations are generally considered disease states. The objective of biomedicine is to identify the mechanisms underlying regulation of set points.