Descriptive statistics were determined. Independent sample t-test and one-way variance test

were utilized for continuous variables and chi-square test for dichotomous variables. Results: The mean INR value for all patients was 1.2 +/- 0.3. The INR value was significantly associated with the diagnosis of liver cirrhosis, the diagnoses of Hepatitis B and C together, the presence of ascites alone, and the number of clinical signs and symptoms (i.e. ascites, jaundice and encephalopathy) present. GANT61 Nine patients with INR values between 1.5 and 2 underwent invasive dental procedures without postoperative bleeding complications. Conclusion: There were no episodes of postoperative bleeding in patients. The findings suggest that clinicians should not rely solely on an INR value to predict post-procedure bleeding in patients with liver disease.”
“Heating of the bromination product of 4-methyl-3,6-dihydro-2H-pyran

with 4-toluidine or 2-bromo-4-methylamiline in triethylamine gave 4-methyl-N-(4-methylphenyl)- and N-(2-bromo-4-methylphenyl)-4-methyl-3,6-dihydro-2H-pyran-3-amines which were converted into the corresponding amides by reaction with bromo-or chloroacetyl chloride. 1-4a,6-Dimethyl-4a,9a-dihydropyrano[3,4-b]indol-9(1H)-yl-ethanone was synthesized in good yield by heating N-(2-bromo-4-methylphenyl)-N-(4-methyl-3,6-dihydro-2H-pyran-3-yl)acetamide in boiling toluene in the presence of palladium(II)acetate, triphenylphosphine, copper(II) acetate, triethylamine, and potassium carbonate.”
“Bilateral infarction of the medial medulla (MMI) is rare. Limited BMS-345541 cell line information is available on clinical characteristics, etiology, and prognosis. High-resolution neuroimaging has a major role in elucidating the underlying stroke mechanism. The aim of this systematic

check details review was to analyze the clinical presentations, stroke mechanisms, and outcomes in patients with bilateral MMI. We performed a systematic review of the literature from 1992-2011 that reported on clinical presentations, stroke mechanism, and/or outcomes in patients with magnetic resonance imaging-proven bilateral MMI. Medline, EMBASE, and Web of Science Scholars Portal were searched without language restriction. Two reviewers independently assessed identified studies to determine eligibility, validity, and quality. The primary outcome was inpatient mortality; a secondary outcome was case fatality at 12 months. We identified 138 articles from Medline, EMBASE, and Scholars Portal including the MeSH terms “”brainstem infarction,”" “”medulla,”" and “”bilateral.”" Twenty-nine articles met our inclusion criteria, including a total of 38 cases with bilateral MMI, and included in our study. These 38 patients had a mean age of 62.2 years and were predominately male (74.2%). The most common clinical presentations were motor weakness in 78.4%, dysarthria in 48.6%, and hypoglossal palsy in 40.5%. The most common vascular pathology was vertebral artery atherosclerosis, in 38.5%.