Each section is further subdivided into relevant subsections with a bulleted format for the accompanying text. A key facts box provides an at a glance summary of the most important points. For each entity the accompanying text (in most cases) covers two

to four pages. There then follows several pages of uniformly high-quality microscope pictures (along with occasional pertinent macroscopic pictures, Trametinib supplier line drawings or CT/MRI images), six to each page. These are accompanied by detailed text to highlight the relevant features. Aspects of the book which I found particularly useful are the inclusion of a detailed section on neoplastic sellar region pathology (something which sometimes seems neglected in large textbooks of neuropathology) selleck chemical and the inclusion of just over 200 pages worth of non-neoplastic pathology (which is as richly illustrated as the neoplastic section). An unusual but not unwelcome addition is a short but informative 24-page antibody and molecular

factors index. The antibody section includes tables listing diagnostic antibodies, a brief description of alternative names and clones, and the chapters within which they are included. The molecular factors section includes a list of molecular factors, chromosomal locations and definitions/alternate names. I particularly like the ‘mixed oligoastrocytoma’ chapter. Each picture shows a single tumour, with the image divided into parts A and B to illustrate the oligodendroglial and astrocytic elements, along with the relevant molecular profile. Given the variations in each pathologists’ threshold for diagnosing a mixed tumour I found it intriguing to see

the authors’ assessment of each case (and compare it with my own). As noted in the preface there is good coverage of a number of entities ‘that while not new, Cediranib (AZD2171) are generally not in the vocabulary of most pathologists’. These include angiocentric glioma, papillary glioneuronal tumour, rosette forming glioneuronal tumour and various other lesions that are infrequently seen in routine practice. The book includes 2700 images. The preface notes that this allows the book to display classic pathological features while also illustrating variant patterns that are prone to create diagnostic problems. I agree with this point whole heartedly, the wealth of high-quality images certainly makes this book stand out from the competition. The whole package is delivered in a sturdy A4 size hardback book. An unusual feature is the lack of conventional page numbers. The book index instead refers to entries by part, section and page, so that I (3): 52 refers to part I, section 3, page 52. This felt a little cumbersome initially but was easy to get used to. Also included in the purchase price if online access to ‘eBook Advantage’. This includes searchable content and a complete antibody list with continuous updates.