Statistically significant at p 0.05. Results Of the 72 women, seven women with two aspects erismodegib LDE225 of ultrasound and serum progesterone levels anovulatory 8 IU / ml were excluded from the study. In addition, three women refused to take the CO after the initial evaluation, because it is the goal of their treatment VER Changed, go to Ren pregnancy, And five were excluded from the study because their relationship ended before it began OK. Therefore, 57 white S women in the age group 18 48 years with the menstrual cycle L Length 25-32 days, the duration of the menstrual 5 2.1 days, and with BMI 21.3 3.7 kg / m 2 in the sample included that evaluated clinically and statistically. Three persons were not shown in the sixth round of monitoring. Mild side effects were recorded in the log. Originally, the 16 women identified by the pr Menstrual syndrome, especially joint, muscle and back pain, Kr Vapors, abdominal pain, breast tenderness, mild headaches and can be influenced. All the symptoms of PMS have been reduced during the first three cycles of OC administration. In addition, all subjects reported relief of symptoms On my sixth round of monitoring. However, adverse events resulted in need during the first three cycles of OC administration, five women had breakthrough bleeding, nausea, five reported mild headache had four, and six chest without thinking about it. Closing Lich had seven and 11 women, and amenorrhea or hypomenorrhea. Table 1 shows the serum concentration JNK Signaling of SHBG, DHEAS, testosterone, FAI and calculating observed at the beginning and the sixth cycle E2V/DNG recording. SHBG increased during OC intake Ht, on the contrary, both DHEAS and testosterone, decreased but this was not statistically significant. Closing Lich ISP reduction in the sixth round of monitoring was observed. Figure 3 shows the Ver Changes in the SF-36 scores at 3 and 6 cycles of OC administration compared with baseline. Women reported Lebensqualit t improve people were taking hours Higher than the obtained at 14 days after the reference. Discussion This study was the first study on the effect of a new four-phasic OC-diagram with the natural estrogen E2 with a derivative of 19 nortestosterone DNG on the quality of t combines the sexual life. In addition, estrogen is a step E2V/DNG OC And low progestin stage startup sequence that covers 26 days with two placebo tablets, the blister 28 days. The first two tablets 3 mg E2V have to initiate the endometrium. The n Next five tablets containing 2 mg E2V and DNG 2 mg of a 17 tablet 2 mg and 3 mg DNG E2V followed. Closing Course, there are only two tablets with 1 mg of E2V and two placebo tablets. Therefore DNG proliferation of the endometrium and its sensitivity to progesterone, nominally, to endometrial stromal cells of the stability of t in the middle and sp To produce second phase of the cycle. It is usually not the suppression of estrogen may need during the placebo phase, the symptoms of hormone withdrawal with physiological cycles and traditional Di Th associated OC Dienogest was able to prevent. It depends h Of E2 levels stable throughout the 28 days Similar values Strogenen in the follicular phase of the menstrual cycle physiology. E2 is the st Strongest natural estrogen Produced by the female gonads and has a limited effect on h Hemostatic parameters in relation to those induced by EA when the dose is considered the Equivalent performance.