Celecoxib and rofecoxib not stero Ans inflammatory stero Dian that selectively inhibit cyclooxygenase-2. They were introduced on the market in 1999 and quickly became news on the hour Most common prescribed medications in the United States. These Flt Signaling drugs are clinically to treat pain and inflammation. COX 1 and COX 2 convert arachidonic acid To prostaglandin H2, which is then converted to a variety of prostano Of including normal prostaglandins, thromboxanes and prostacyclins. Thromboxane A2, the product of COX activity of 1-t Ttchen in blood platelets, F Promotes vasoconstriction, proliferation of smooth muscle and ttchenaggregation Pl. In contrast, f Prostacyclin promoted by COX-2 in blood vessels W Ttchenaggregation ligands produced vasodilation and inhibition of blood platelets. As an analgesic anti-inflammatory stero Dian, the COX-2 as an improvement over less selective COX-1, COX-2 inhibitors because they the synthesis of prostaglandins, which cause inflammation and inhibit pain, while sparing some positive effects of the COX 1 prostano the generated. However, these drugs have been the subject of scrutiny in 2004, when voluntarily withdrew Vioxx from the market because. One obtains HTES risk for heart attack and stroke in patients who ume the drug for L Ngere ZEITR A systematic verification of randomized clinical trials of COX showed that rofecoxib, a highly selective COX-2 agent, and diclofenac, an NSAID with COX-2-selective COX-1 Similar to celecoxib, both significantly increased Hte risk kardiovaskul re events.
However, a number Tyrphostin AG-1478 of clinical studies have not increased HTES kardiovaskul Higher risk with celecoxib compared with placebo demonstrated. The reasons for the differences between celecoxib and other COX-2 are still widely debated. K antihypertensive effect Nnte Less cardiovascular complications that lead with celecoxib compared to other COX-2. Meta-analysis of 19 clinical trials with COX-2 inhibitors showed a significantly lower risk of developing high blood pressure in patients with celecoxib compared with rofecoxib treatment. Likewise showed a retrospective analysis of medical records of patients with celecoxib or rofecoxib over a period of 90 days of treatment, that w While the systolic blood pressure increased significantly after 90 days in patients with rofecoxib Ht, systolic blood pressure slightly R??ckl Frequently celecoxibtreated patients. Several recent studies have found Relaxing effect of celecoxib, the k their different effects on blood pressure compared to other COX-2 Nnte explained Ren says. In this article, we explored the mechanisms that found the Widening effect underlie Nnten k, And a lower risk of cardiovascular complications for celecoxib, which re the effects of NSAIDs on celecoxib and other Vaskul Smooth muscle Ionenkan le and physiological functions. We focused our attention on two types of Ionenkan len, perhaps the most important in determining the contractile state of smooth muscle cells: Len K-Kan, which determine the resting tension of the membrane voltage, and L type gated Ca 2 cannula whose activation induced Ca2 influx, smooth