Furthermore, compared to wild-type mice, DJ-1 null mouse brain homogenates and embryonic fibroblasts were more susceptible to oxidant-induced selleck kinase inhibitor dissociation of ASK1 from Trx1,activation of the downstream kinase c-Jun N-terminal kinase, and to cell death. These findings point to yet another mechanism through which DJ-1 has anti-oxidant and cytoprotective
properties by regulating the Trx1/ASK1 complex and controlling the availability of ASK1 to effect apoptosis. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.”
“Purpose: Rectourethral fistula is a rare but severe complication after radical prostatectomy and there is no standardized treatment. We retrospectively evaluated the incidence, symptoms and management Selleckchem PU-H71 of rectourethral fistulas based on our experience.
Materials and Methods: From 1999 to 2008 we perfomed 2,447 radical prostatectomies. Patients in whom postoperative rectourethral fistulas developed were identified.
Based on the therapeutic approach patients were categorized into group 1-conservative treatment, group 2-colostomy with or without surgical closure and group 3-immediate surgical closure without colostomy.
Results: Rectourethral fistulas developed in 13 of 2,447 patients (0.53%) after radical prostatectomy. The risk of rectourethral fistulas was 3.06-fold higher (p = 0.074) for perineal (7 of 675, 1.04%) than for retropubic prostatectomy (6 of 1,772, 0.34%). In 7 of 13 patients (54%) a rectal lesion was primarily closed at radical prostatectomy. Median followup was 59 months. In all patients in group 1 (3) the fistula closed spontaneously with conservative treatment. None of these patients had fecaluria. In group 2 of the 9 patients 3 (33%) experienced spontaneous fistula closure after temporary colostomy and transurethral catheterization. In this group 6 patients (67%) required additional surgical
Galactokinase fistula closure, which was successful in all. Surgical fistula closure (1) without colostomy in presence of fecaluria failed (group 3).
Conclusions: The therapeutic concept for rectourethral fistulas should be guided by clinical symptoms. Rectal injury during radical prostatectomy is a major risk factor. In cases with fecaluria colostomy is required for control of infection and may allow spontaneous fistula closure in approximately a third of cases. In the remainder of cases surgical fistula closure was successful in all after protective colostomy.”
“Trans-2,4-dimethoxystibene (S-3) is a synthetic stilbene. In this study. S-3 was investigated in terms of its neuroprotective effect against the toxicity induced by beta-amyloid(25-35) (A beta(25-35)) both in vitro and in vivo. Protection by S-3 was studied at the in vivo level using a model of intracerebroventricular (i.c.v.) injection of AB(25-35) in mice. The consumption of S-3 (50 mg/kg) significantly ameliorated the cognitive deficits and neuron apoptosis caused by i.c.v.