In intact follicles and in theca cells, IGF-I and b-insulin had no effect on HCG-stimulated testosterone production. HCG-stimulated 17 beta-estradiol production, however, was significantly increased by IGF-I and b-insulin. To clarify the mechanism of 17 beta-estradiol production by the ovarian follicles during vitellogenic H 89 clinical trial stage of carp, effects of IGF-I and b-insulin
either alone or in combination with HCG on aromatase activity (conversion of testosterone to 17 beta-estradiol) and cytochrome P450 aromatase (P450arom) gene expression were investigated in vitro. IGF-I and b-insulin alone stimulated aromatase activity and P450arom gene expression and significantly AC220 enhanced HCG-induced enzyme activity and P450arom gene expression. Our results thus indicate that IGF-I and b-insulin alone can stimulate testosterone and 17 beta-estradiol production in vitellogenic follicles of C. carpio by stimulating aromatase activity and P450arom gene expression. Evidence also provided for
the modulation of HCG-induced aromatase activity and P450arom gene expression by IGF-I and b-insulin in such follicles. (C) 2009 Elsevier Ireland Ltd. All rights reserved.”
“OBJECTIVE: Although a dural or intramedullary arteriovenous fistula involving the conus medullaris and fed by the lateral sacral artery has been reported, a case of perimedullary fistula arising from an artery in the filum terminale has not been described in the literature. The authors report the first case of perimedullary arteriovenous fistula located in the filum terminale.\n\nCLINICAL PRESENTATION: A 61-year-old man presented with a 10-year history
of leg pain. Thoracolumbar magnetic resonance imaging scans revealed multiple perimedullary signal voids from T10 to L3. Angiography showed engorged perimedullary veins and a fistula fed by the anterior spinal artery from the right ninth segmental artery and by 2 branches of the left lateral sacral artery. The anterior spinal artery was also regarded as the artery of the filum terminale.\n\nINTERVENTION: Transarterial embolization was performed to occlude BIIB057 mw the feeders from the left lateral sacral artery, and an L5 total laminectomy was subsequently performed to obliterate residual fistulous material from the artery of the filum terminale. The thickened, yellowish filum, surrounded by tortuous, engorged veins, was coagulated and 4 resected. Postoperatively, the patient’s symptoms gradually resolved and were not aggravated during long periods of walking.\n\nCONCLUSION: It must be noted that a fistula can be located in the filum terminale and can be successfully treated using multidisciplinary approaches.