a href=”http://www.selleckbio.com/ku-55933-S1092.html”>KU-55933 influenzae and M. catarrhalis isolates with ABT 492, compared with 71% to levofloxacin. A time to the online activity Th of ABT 492 and levofloxacin is opposed to any bacterial species and the quinolones p t Th pneumoniae isolate in Figure 1 Plots of log10 CFU per milliliter of time compared to all isolates analyzes show konzentrationsabh Independent bactericidal activity of t. Erh Hte concentrations of ABT 492 and levofloxacin led to an increase ever Increase the speed and magnitude of bactericidal activity. The sigmoidal model results Of, plotted as the antibacterial activity Th to both quinolones concentrations after 4, 6 and 12 h of exposure to quinolones in S. pneumoniae used in the comparison in Fig sensitive second The resistance of S.
pneumoniae isolate to quinolones was not included in the analysis pneumoniae S., because the results differ from time to t Th data significantly from the figure. First Dead-time curves for the four clinical isolates. Left 17-DMAG curves represent the activity t of ABT 492 and repr curves on the right side Sentieren the activity t of levofloxacin against the same isolate. OE, tax The,, 0.0625 times the MIC, 0.125 times the MIC-, 0.25-times the MIC, 0.5 times the MIC, ƒ, 1 times the MIC, two times the MIC E, four times the MIC, F, 8-fold the MIC. VOL. 48, 2004 out action ABT 492 against respiratory pathogens data for 205 quinolone-sensitive isolates. The results of the sigma-models Of Emax for H. influenzae and M. catarrhalis were Similar to those of S. pneumoniae and are therefore not shown.
The EC50, EC90 and Emax obtained the data from all plots are shown in Table 2. The EC 50 for all isolates ranged from 0.884 to 1.96 times the MIC. The EC90s for all isolates ranged from 1.270 to 6383 times the MIC. With the exposure time, increases hte maximum Bakterienabt Tion effect and the multiple of the MIC required to achieve the EC90 decreased au h It at 24 when the EC 50 were compared by ABT 492 with those of levofloxacin, were the values within the standard error of the other 2 and 4 h for S. pneumoniae and H. influenzae, respectively. After 12 h exposure to 24 antibacterial, EC50 was lower than that of levofloxacin of ABT 492, au In the case of H. influenzae it. DISCUSSION ABT 492 is a novel fluoroquinolone which is currently under development. This compound has antibacterial activity of t Fig improved.
Second Composite concentration-response curves for penicillin-sensitive S. pneumoniae and penicillin-resistant isolates of S. pneumoniae to antibiotics after exposure to ABT 492 and levofloxacin at 4, 6 and 12 hours. 206 Gunderson et al. Antimicrob. Agents Chemother. against a variety of pathogens, including normal isolates resistant to fluoroquinolones. In this study we have characterized its pharmacodynamic and compared to the killing with levofloxacin MIC determinations and in vitro time kinetic studies. As mentioned HNT, ABT 492 has very low MICs if it was against gram-positive and gram-negative isolates. The best performance was by other researchers CONFIRMS been and extends to other bacterial species. The fact that these low MIC is with in vivo activity of t free of the antibiotic concentration achievable at the site of the infection depends correlate Dependent. Concentration can be achieved without an antimicrobial h Depends on its binding protein, tissue distribution and the therapeutic index. W While the tissue distribution and safety profile for ABT 492 are not always