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and performed the experiment, analyzed the data, and NF-��B inhibitor helped draft the manuscript. CML helped draft the manuscript. WCY conceived the study, participated in its design and coordination, and helped with the manuscript preparation. CHL helped draft the manuscript. All authors read and approved the final manuscript.”
“Background Several therapeutic anticancer drugs, although pharmacologically effective in cancer treatment, are restricted in their clinical applications because of their severe toxicity [1]. The severe toxicity is usually due to the lipid solubility of most of the anticancer drugs (>70%) and the therapeutic doses that are often very high [2]. Doxorubicin is one of the most successful drugs for targeting a broad range of cancers. Nevertheless, its clinical use is hindered by its side effects, which include cardiotoxicity and acquired drug resistance. To overcome these complications, researchers have placed an emphasis on developing nanoscale anticancer drug carriers for improving therapeutic efficacy in addition to reducing unwanted side effects [3].