Learning Objectives: Explain the latest insights into the molecular and cellular mechanisms
XL184 for ALD Define the current challenges in the diagnosis and treatment of ALD Identify different federal agencies interested in research on alcoholic hepatitis and alcoholic liver disease Discuss the role of drug discovery and complementary medicine in ALD Session I: Clinical and Translational Research: Focus on Severe Acute Alcoholic Hepatitis MODERATORS: Craig J. McClain, MD Samir Zakhari, PRD 1:00 – 1:20 PM Development of Improved Scoring Methods for the Diagnosis and Treatment of Severe Acute Alcoholic Hepatitis Philippe Mathurin, MD, PhD 1:20 -1:25 PM Q&A 1:25 – 1:45 PM Acute Complications in ASH: Role in Prognosis and Treatment Strategies Ramón Bataller, MD 1:45 – 1:50 PM Q&A 1:50 – 2:10 PM Towards
RXDX-106 purchase Personalized Medicine: Development of Biomarkers for Improved Therapeutics In ALD Christopher Leptak, MD, PhD 2:10 – 2:15 PM Q&A 2:15 – 2:45 PM Panel Discussion: Funding Opportunities to Support Research on ALD Gary J. Murray, PhD and Kenneth R. Warren, PhD 2:45 – 3:05 PM Break Session II: Basic Mechanisms: Focus on Inter-organ Interactions in ALD MODERATORS: Laura E. Nagy, PhD Ali Keshavarzian, MD 3:05 – 3:25 PM Dysregulation of the Gut Microbiome in ALD Bernd Schnabl, MD 3:25 – 3:30 PM Q&A 3:30 – 3:50 PM Monocyte Recruitment to the Liver and Adipose in ALD Cynthia Ju, PhD 3:50 – 3:55 PM Q&A Panel discussion: NIAAA Funded UO1 Translational Research in Alcoholic Hepatitis MODERATORS: Laura E. Nagy, PhD Craig J. McClain, MD 3:55 – 4:05 PM Goals and Structure of UO1 Translational Research in Alcoholic Hepatitis Gary J. Murray, PhD Brief overview: Aims by each of the funded
consortiums 4:05 – 4:15 PM David W. Crabb, MD 4:15 – 4:25 PM Gyongyi Szabo, MD, PhD 4:25 – 4:35 PM Ramón Bataller, MD 4:35 – 4:45 PM Timothy R. Morgan, MD 4:45 – 5:00 PM Q&A for NIAAA Panel/Consortia President’s Choice Sunday, November Fenbendazole 3 2:00 – 2:30 PM Hall E/General Session Random Germline Mutagenesis in the Analysis of Immunity SPEAKER: Nobel Laureat, Bruce A. Beutler, MD MODERATOR: J. Gregory Fitz, MD This lecture will describe how a classical genetic approach can be used to provide a list of the causes of inherited disease; how it has become practical to saturate the genome of the mouse with mutations and assigns cause and effect. Bruce Beutler is a Regental Professor and Director of the Center for the Genetics of Host Defense at UT Southwestern Medical Center in Dallas, Texas. In 2011, he shared the Nobel Prize in Physiology or Medicine for “discoveries concerning the activation of innate immunity. Dr. Beutler received his medical training at the University of Chicago, graduating in 1981.