Methods: Two hundred asymptomatic volunteers with no prior hip surgery or childhood hip problems underwent magnetic resonance imaging targeted to both hips. The subjects were examined at the time of magnetic resonance imaging for internal

rotation of the hips at 90 degrees of hip flexion and for a positive impingement sign. The contour of the femoral head-neck junction was quantified with use of the alpha angle. A value of >50.5 degrees was considered positive for cam morphology. Measurements were performed independently by two musculoskeletal radiologists.

Results: The mean age of the individuals was 29.4 years (range, 21.4 to 50.6 years); 79% were white, and 55.5% were women. The mean alpha angle anteriorly at the three RSL3 clinical trial o’clock position was 40.9 degrees +/- 7.0 degrees on the right and 40.6 degrees +/- 7.1 degrees on the left, ABT737 whereas the mean alpha angle anterosuperiorly at the 1:30 position was 50.2 degrees +/- 8.0 degrees on the right and 50.1 degrees +/- 8.3 degrees on the left. Fourteen percent of the

volunteers had at least one hip with cam morphology: 10.5% had an elevated alpha angle on either the right or the left side, and 3.5% had the deformity in both hips. Seventy-nine percent (twenty-two) of twenty-eight individuals who had an elevated alpha angle were men, and 21%(six) were women. Individuals with an elevated alpha angle on at least one side tended to be male (p < 0.001), with 24.7% (twenty-two) of eighty-nine men having cam morphology compared with only 5.4% (six) of 111 women.

Conclusions: The prevalence of cam-type femoroacetabular impingement deformity is higher in men as well as in individuals

with decreased internal rotation. Defining what represents Anlotinib manufacturer a normal head-neck contour is important for establishing treatment strategies in patients presenting with prearthritic hip pain.”
“Subject- and physician-reported data from 4,429 postmenopausal women receiving osteoporosis treatment in the Prospective Observational Scientific Study Investigating Bone Loss Experience (POSSIBLE US) were used to assess the prevalence of risk factors (RFs) and on-study fracture. RFs assessed at study entry were age >70 years; fracture since age 50; minimum T-score (hip/spine) <= -2.5 at diagnosis; body mass index <18.5kg/m(2); rheumatoid arthritis; parental history of hip fracture; current smoking; and recent oral glucocorticoid use. Data were collected with semiannual self-administered questionnaires. Results were stratified by physician-reported osteoporosis/osteopenia diagnosis. Low T-score and age >70 years were the most common RFs in the osteoporosis group, and age >70 years and prior fracture were the most common risk factors in the osteopenia group. Multiple RFs were more common than a single RF in osteoporotic women (54.2% versus 34.6%; P < 0.0001) but not osteopenic women (13.8% versus 33.6%; P < 0.0001).