\n\nMethods\n\nAssociation studies of the COMT val158met polymorphism and anxiety traits were identified from the PubMed or PsycInfo databases, conference abstracts, and listserv postings. Exclusion criteria were (a) pediatric samples, (b) exclusively clinical samples, and (c) samples selected for a nonanxiety phenotype. IPI-549 Standardized mean differences in anxiety between genotypes were aggregated to produce

mean effect sizes across all available samples, and for subgroups stratified by sex and ethnicity (Whites vs. Asians). Construct-specific analysis was conducted to evaluate the association of COMT with neuroticism, harm avoidance, and behavioral inhibition.\n\nResults\n\nTwenty-seven eligible https://www.selleckchem.com/products/p5091-p005091.html studies (N=15 979) with available data were identified. Overall findings indicate sex-specific and ethnic-specific effects: valine homozygotes had higher neuroticism than methionine homozygotes in studies of White males

[mean effect size=0.13; 95% CI 0.02, 0.25; P=0.03], and higher harm avoidance in studies of Asian males (=0.43; 95% CI 0.14, 0.72; P=0.004). No significant associations were found in women and effect sizes were diminished when studies were aggregated across ethnicity or anxiety traits.\n\nConclusion\n\nThis meta-analysis provides evidence for sex and ethnic differences in the association of the COMT val158met polymorphism with anxiety traits. Our findings contribute to current knowledge on the relation between prefrontal dopaminergic

transmission and anxiety.”
“A colony of Dolichovespula media (Reitz) is reported for the first time in Turkey. Morphological variation within the colony is reported. There were two and three distinctively different forms among females and males, respectively. A description of the nest is reported.”
“Background\n\nTraumatic Traumatic head injury is a common occurrence in the paediatric population, with the majority of patients sustaining only mild head injury.\n\nObjective\n\nThis article outlines the management of mild head injuries in children.\n\nDiscussion\n\nA careful history including time of injury, the mechanism of injury, and any loss of consciousness or seizure activity; CH5424802 order a thorough examination including a Glascow Coma Scale (GCS) score; and observation should be appropriate for most patients. Only a small number of injuries require further examination/imaging with computerised tomography. Indicators for transfer to hospital include GCS equal to or less than 12, focal neurological deficit, clinical evidence of skull fracture, loss of consciousness for more than 30 seconds, ataxia, amnesia, abnormal drowsiness, persistent headache, seizure following initial normal behaviour or recurrent vomiting.