Microscopically, any pathological lesion [i.e. fibrocystic disease (FCD), adenosis, Crenolanib PDGFR inhibitor duct ectasia as well as epithelial hyperplasia] and its grade were noted. Epithelial hyperplasia was classified as ��usual, which is not considered premalignant�� or ��atipical, which is considered premalignant�� (11). Usual hyperplasia is also graded as ��mild, moderate, or severe��. Results Fourty patients with innocent radiological imaging without history of breast malignancy or previous surgery were included. The mean age at the time of BR was 45,6 years (range 20�C59). The consistency of breast parenchyma was fatty in 19 and 20 out of 40 right and left breasts, respectively. Predominantly fibrosy breast was seen in 3 patients. No records was present for the consistency of 3 patients in the pathology report.

The mean number of sample microscopically examined was 5,5 for right breast (range 2�C13) and 5,7 for left breast (range 2�C13). Gross examination revealed cyst in 3 breasts from two patients. The rest of the breasts were recorded macroscopically unremarkable. Besides its innocuous-looking macroscopically, microscopic examination yealded cysts, fibrocystic disease, fibroadenoma, epithelial hyperplasia, duct ectasia, sclerosing adenosis, lobular or periductal mastitis, lobular neoplasia in 27 women (67,5%) (Table 1); 20 of them had unilateral breast lesions. We noted that most of the histopathological lesions indicate benign lesions, i.e. fibrocystic disease (43,5%), adenosis and blunt duct adenosis (5%), sclerosing adenosis (2,5%), ductal ectasia (7,5%), ductal or lobular mastitis (8,7%), fibroadenoma (1,2%).

Mild usual hyperplasia was found in 7 breasts (8,7%), moderate hyperplasia were found in 5 breasts (6,2%) from 5 patients who were 47, 56, 47, 38 and 59 years old, respectively, and low grade lobular neoplasia was found in 2 breasts (2,5%) from same patient who was 45-year old. We haven��t seen severe or atypical hyperplasia or any invasive or in situ carcinoma and breasts from 13 women (32,5%) with completely innocuous breast tissue either radiologically and histopathologically. Table 1 OVERALL HISTOPATHOLOGICAL FINDINGS IN 27 BR SPECIMENS. Discussion Due to slight but definite incidence of premalignant and malignant lesions found at breast reduction materials, surgeons preoperatively perform a through breast examination and radiological test and then send BR specimens for histopathological analysis (2).

There is significant discrepancy between radiologic tests and histopathological analysis in practice (2, 8�C10, 12). Some surgeons prefer a mandatory mammograms in all patients undergoing BR irrespective of age and others prefer USG in patients under 30 years old or younger (6). The majority of the surgeon, on the other hand, prefer to send BR specimen to pathology Carfilzomib laboratory. The proportion of surgeons who never send BR specimens for pathology laboratory has decreased from 11% to 1% during the last 15 years (2).