Pathogenic bacteria are those that are harmful to the host. TAM Receptor inhibitor Microbial biofilm communities on the subgingival tooth surfaces subjacent to the gingival tissues are composed of approximately 700 species [8,14]. The microbial ecology of the subgingival environments of periodontally healthy and periodontally diseased sites are distinct [6,8,14]. Accumulation of tooth-associated bacterial biofilm (plaque) elicits gingival inflammation as a result of bacterial virulence factors and vascular dilation. In sites colonized by

pathogen-dominated biofilms the inflammatory response results in destruction of connective tissue and alveolar bone, the classic features of periodontitis. The tissue destruction is actually a result of the host response elicited by the pathogens, rather than direct toxic/noxious actions

of the bacterial virulence factors [15,16]. The immune system is comprised of both innate and adaptive immune responses that are used to manage bacterial infections. The adaptive immune response results from a cognate interaction of receptors on immune cells engaging antigens as ligands, resulting in the initiation of cell-mediated and/or https://www.selleckchem.com/products/jq1.html humoral immune responses. Antigenic triggering of immunoglobulin receptors on B cells leads to maturation and differentiation into plasmacytes that produce antibody are the effector molecules of humoral immunity [16,17]. Important to the objectives of this project, the host oral cavity is colonized routinely by a range of commensal bacteria, as well as a varied number of potentially pathogenic species. While these bacteria all represent ‘non-self’, it remains

unclear how the immune system differentiates commensals that are important to maintain for health from those bacteria with greater virulence capabilities [8]. It has been suggested that the immune system has the ability to recognize commensal bacteria differently from pathogens, thus leading to heptaminol a different type of immune response [13,17,18]. However, the details of these characteristics, specifically with regard to the oral cavity, remain to be determined. Various environmental factors affect the microbial composition in the oral cavity, as well as the host response. While smoking is a well-recognized risk factor for periodontal attachment loss, smokers often exhibit less gingival bleeding than would be predicted [19]. This is due probably to effects of the toxic cigarette chemicals on the local vascular functions [19,20]. Minimal data are available to compare the potential effect of smoking on the immune system discrimination of commensals from pathogenic oral bacteria. Data analysis was performed to address two central objectives for the study: (i) to determine the level of immunoglobulin (Ig)G antibody to periodontal pathogens and oral commensal bacteria in smokers; and (ii) to determine how antibody responses are affected by the extent of smoking and degree of periodontal disease.