Table 1. Demographic information Sample two. In this study, 463 adult smokers were randomized to one of four experimental conditions: (a) active bupropion SR (150 mg, twice daily) and selleck chemicals llc counseling, (b) active bupropion SR without counseling, (c) placebo bupropion SR and counseling, and (d) placebo bupropion SR without counseling. Counseling consisted of two prequit and six postquit 10-min individual sessions in the first month after the quit date. Pharmacotherapy started 1-week prequit and continued for 8 weeks postquit. Table 1 provides demographic and smoking history information for these participants. Eligibility criteria were the same as for sample one. Sample three.

In this study, 410 adult smokers were randomly assigned to one of four experimental conditions: (a) nicotine lozenge (2 or 4 mg) and quitline services, (b) nicotine lozenge (2 or 4 mg) and a self-help brochure, (c) nicotine gum (2 mg) and quitline services, or (d) nicotine gum (2 mg) and a self-help brochure. The quitline services consisted of four telephone counseling sessions, initiated by the quitline. The self-help brochure was the 2000 U.S. Public Health Service ��You Can Quit�� brochure. Pharmacotherapy started 1-week prequit and continued for 8 weeks postquit. Table 1 provides demographic and smoking history information for these participants. Eligibility criteria were the same as for sample one. Procedure The procedures for the three studies were similar. Participants attended an orientation session, at which they learned about the study and provided written informed consent.

Participants then attended assessment sessions, during which they were screened for eligibility and completed a series of questionnaires (described in the Measures section). Eligible individuals were then randomized to a treatment group. Participants completed the treatment phase and were followed-up monthly after treatment to assess continuous and 1-week point prevalence abstinence. Individuals who reported point prevalence abstinence at 6 months were invited to come back to the clinic for a CO test to confirm their abstinence. Measures Demographics and smoking history. A demographics questionnaire assessed characteristics such as gender, ethnicity, age, marital status, education level, and employment.

The Smoking History Questionnaire included items such as the number of cigarettes smoked per day, age at smoking initiation, number of quit attempts, longest time abstinent after smoking initiation, and presence of other smokers in the household. Direct Assay of Dependence Criteria. The Direct Cilengitide Assay of Dependence Criteria comprised 14 items designed to assess three nicotine dependence�Crelated constructs: relapse likelihood, withdrawal symptoms, and cigarette self-administration. Each item was answered on a 7-point Likert scale. This measure was developed by the study authors for use in the clinical trials described earlier. Fagerstr?m Test for Nicotine Dependence.