Intact epidermal cysts, similarly, showcase arborizing telangiectasia; however, ruptured epidermal cysts demonstrate peripheral, linearly branching vessels (45). Dermoscopic examination of steatocystoma multiplex and milia often reveals a peripheral brown rim, linear vessels, and a uniform yellow background across the entire lesion, as documented in reference (5). Importantly, the cystic lesions previously described are characterized by linear vessels, in contrast to pilonidal cysts, which exhibit a pattern of dotted, glomerular, and hairpin-shaped vessels. Pilonidal cyst disease, amelanotic melanoma, basal cell carcinoma, squamous cell carcinoma, pyogenic granuloma, lymphoma, and pseudolymphoma should be part of the differential diagnostic evaluation for pink nodular lesions (3). Dermoscopic features frequently associated with pilonidal cyst disease, as per our cases and the two published cases, comprise a pink backdrop, central ulceration, peripherally arranged dotted vessels, and white linear patterns. Central yellowish, structureless areas, along with peripheral hairpin and glomerular vessels, are dermoscopically observed features of pilonidal cyst disease, as per our findings. Ultimately, the previously mentioned dermoscopic signs allow for a clear differentiation of pilonidal cysts from other skin tumors, and dermoscopy supports a clinical diagnosis of pilonidal cyst in appropriate cases. To more thoroughly characterize the typical dermoscopic signs of this disease and their frequency, additional research is required.

Esteemed Editor, segmental Darier disease (DD) stands as a rare medical condition, with approximately forty documented instances referenced in English-language publications. One proposed cause of the disease is a post-zygotic somatic mutation in the calcium ATPase pump, which is localized exclusively to lesional skin. Patients with segmental DD, specifically type 1, showcase lesions that follow Blaschko's lines on one side of the body; type 2, conversely, displays focal areas of heightened severity within the context of generalized DD (1). Diagnosing type 1 segmental DD is problematic due to the lack of a positive family history, the condition's late manifestation in the third or fourth decade, and the absence of identifiable DD-related features. Within the differential diagnosis of type 1 segmental DD, acquired papular dermatoses, exemplified by lichen planus, psoriasis, lichen striatus, or linear porokeratosis, are characterized by a linear or zosteriform arrangement (2). We highlight two cases of segmental DD; the first, a 43-year-old female, displayed pruritic skin conditions for five years, with symptoms exacerbated by seasonal factors. The left abdominal and inframammary regions exhibited a swirling array of small, keratotic papules, light brownish to reddish in hue, as observed during the examination (Figure 1a). Polygonal or roundish yellowish-brown patches, encompassed by a whitish, structureless border, were evident in the dermoscopic image (Figure 1b). type 2 immune diseases The histopathological findings in the biopsy specimen (Figure 1, c) align with dermoscopic brownish polygonal or round areas, exhibiting hyperkeratosis, parakeratosis, and dyskeratotic keratinocytes. A discernible improvement in the patient's condition, as seen in Figure 1, subfigure d, was attributed to the 0.1% tretinoin gel prescription. In the second case, a 62-year-old female presented with a zosteriform rash on her right upper abdomen, consisting of small red-brown papules, eroded papules, and yellowish crusts (Figure 2a). The dermoscopic image (Figure 2b) showed polygonal, roundish, yellowish areas that were surrounded by structureless areas of whitish and reddish coloration. Microscopic examination revealed the key features of compact orthokeratosis, interspersed with small parakeratosis foci. Dyskeratotic keratinocytes within a marked granular layer and suprabasal acantholytic foci supported the diagnosis of DD (Figure 2, d, d). As a consequence of being prescribed topical steroid cream and 0.1% adapalene cream, the patient's condition displayed an improvement. Clinico-histopathologic correlation led to a final diagnosis of type 1 segmental DD in both cases; acantholytic dyskeratotic epidermal nevus, indistinguishable in both clinical and histological presentations from segmental DD, could not be excluded from the diagnosis solely based on the histopathological findings. Although onset occurred late and the condition worsened due to external factors such as heat, sunlight, and sweat, the diagnosis of segmental DD remained plausible. The final diagnosis of type 1 segmental DD is typically made through a synthesis of clinical and histological evaluation; yet, dermoscopy plays an essential role by helping eliminate other potential diagnoses, identifying and acknowledging their distinct dermoscopic hallmarks.

While the urethra is not frequently a site of condyloma acuminatum, its appearance, if present, is generally concentrated near the distal end. Urethral condylomas are addressed through a spectrum of treatment options. Variable and extensive treatments incorporate laser treatment, electrosurgery, cryotherapy, and topically applied cytotoxic agents, including 80% trichloroacetic acid, 5-fluorouracil cream (5-FU), podophyllin, podophyllotoxin, and imiquimod. For treating intraurethral condylomata, laser therapy remains the preferred form of treatment. A 25-year-old male patient with meatal intraurethral warts, after facing repeated failure with treatments including laser, electrosurgery, cryotherapy, imiquimod, and 80% trichloroacetic acid, was ultimately cured with 5-FU.

Skin disorders, ichthyoses, encompass a range of conditions, notably erythroderma and extensive scaling. The link between ichthyosis and melanoma has not been thoroughly explored. In this instance, we describe a distinct case of palmar acral melanoma affecting a senior individual with a history of congenital ichthyosis vulgaris. The biopsy sample displayed a superficially spreading melanoma, marked by ulceration. To our knowledge, there are no documented cases of acral melanoma reported in patients with a history of congenital ichthyosis. Patients with ichthyosis vulgaris, however, should undergo regular clinical and dermatoscopic assessments for melanoma, considering the possible spread and growth of the cancer.

A 55-year-old male patient presented with penile squamous cell carcinoma (SCC), a case we detail here. WNK463 The patient's penis housed a mass, incrementally expanding in size. For the removal of the mass, a partial penectomy was performed. The microscopic findings were consistent with a highly differentiated squamous cell carcinoma. A determination of human papillomavirus (HPV) DNA was made possible by employing polymerase chain reaction. The squamous cell carcinoma's HPV presence, identified as type 58, was confirmed through sequencing.

Cutaneous and extracutaneous anomalies frequently coexist, a well-documented feature of numerous genetic syndromes. Nevertheless, the possibility of undiscovered and unnamed symptom combinations persists. Medication use We report a case of a patient admitted to the Dermatology Department for treatment of multiple basal cell carcinomas that developed from a nevus sebaceous. The patient's presentation included cutaneous malignancies, palmoplantar keratoderma, prurigo nodularis, hypothyroidism, multiple lumbar abnormalities, a uterine myoma, an ovarian cyst, and a highly dysplastic colon adenoma. A confluence of multiple disorders might suggest a genetic basis for the ailments.

Following drug exposure, drug-induced vasculitis develops due to inflammation in small blood vessels, potentially harming the affected tissue. Rare instances of drug-induced vasculitis are documented in the literature, particularly those related to chemotherapy treatments, or in conjunction with radiation therapy. A medical diagnosis of small cell lung cancer (SCLC), stage IIIA (cT4N1M0), was confirmed in our patient's case. Following the second cycle of carboplatin and etoposide (CE) chemotherapy, administered four weeks prior, the patient experienced the onset of cutaneous vasculitis and a rash localized to the lower extremities. Symptomatic therapy with methylprednisolone was initiated following the cessation of CE chemotherapy. Patients receiving the prescribed course of corticosteroid treatment saw an upgrade in the local conditions. Completion of chemo-radiotherapy signaled the commencement of four cycles of consolidation chemotherapy incorporating cisplatin, bringing the total number of chemotherapy cycles to six. Further regression of the cutaneous vasculitis was observed during the clinical evaluation. Following completion of the consolidation chemotherapy regimen, elective brain radiotherapy was administered. Disease relapse prompted the cessation of clinical monitoring for the patient. Subsequent chemotherapy cycles were administered to target the platinum-resistant disease. After seventeen months from the initial SCLC diagnosis, the patient departed this world. In our records, this appears to be the first described case of lower limb vasculitis in a patient receiving concomitant radiotherapy and CE chemotherapy as a part of the initial treatment for small cell lung cancer.

Historically, allergic contact dermatitis (ACD) from (meth)acrylates has been a prevalent occupational issue for dentists, printers, and fiberglass workers. Cases of health concerns, stemming from the use of artificial nails, have been recorded, involving both nail technicians and those wearing them. (Meth)acrylates in artificial nails are a significant factor in ACD, raising concerns among both nail technicians and consumers. Severe hand dermatitis, especially on the fingertips, coupled with frequent facial dermatitis, emerged in a 34-year-old woman who had been working in a nail art salon for two years. The patient's artificial nails, in use for the past four months, were a result of her nails' tendency to split, which required regular gel treatment for protection. She reported multiple incidents of asthma during her time at the office. The baseline series, acrylate series, and the patient's own material were subjected to patch testing.