The fractures were analyzed radio-graphically and biomechanically (with torsional testing) five weeks after surgery.
Results: In the ectopic model, there was dose-dependent see more enhancement of rhBMP-2 activity with use of SVAK-12 at doses of 100 to 500 mu g. In the fracture model, the SVAK-12-treated group had significantly higher radiographic healing scores than the untreated group (p = 0.028). Biomechanical testing revealed that the fractured femora in the 200 to 250-mu g SVAK-12 group were 43% stronger (p = 0.008) and 93% stiffer (p = 0.014) than those in the
control group. In summary, at five weeks the femoral fracture group injected with SVAK-12 showed significantly improved radiographic and biomechanical evidence of healing compared with the controls.
Conclusions: A single local dose of a low-molecular-weight compound, SVAK-12, enhanced bone-healing in the presence of low-dose exogenous rhBMP-2 (in the ectopic model) and endogenous rhBMPs (in the femoral fracture model).”
“The combination of piezoelectric materials and single crystal diamond offers the opportunity for the development of multifunctional micromachined devices under extreme conditions. In this work, the authors report the structural, electrical, optical, and dielectric
properties of Pb(Zr-0.52,Ti-0.48)O-3 (PZT) thin films integrated Selinexor on single crystal diamond (100) substrates. The corresponding field effect transistor based on the metal-piezoelectric-insulator-semiconductor BAY 73-4506 (MPIS) structure was fabricated on a homoepitaxial p-type diamond layer grown on a type-Ib diamond substrate. Different intermediate layers were deposited
on single diamond substrates prior to the PZT films growth in order to achieve the best polarization properties. It was observed that the utilization of an Al2O3 buffer layer followed by a SrTiO3 seed layer favored the formation of a single perovskite PZT phase. Transmission electron diffraction patterns revealed that the PZT films included an initial layer at the SrTiO3/PZT interface followed by a well crystallized layer. The PZT film grown on SrTiO3/Al2O3/diamond exhibited much better in-plane polarization than that of the PZT film on Al2O3/diamond. The photoresponse behavior revealed that carriers trapping effect was trivial in the PZT film. The channel electrical conductivity of the MPIS field effect transistor was successfully modulated by the gate bias.”
“Methods: A retrospective analysis of the results of pediatric radiofrequency catheter ablation at a single institution over the most recent 5 years (January 2004 through December 2008) was performed. Acute, intermediate, and long-term success, along with the incidence of AV block, were determined.
Results: There were 65 patients with a mean age of 12.1 +/- 5.2 years and weight of 46.5 +/- 17.3 kg who underwent radiofrequency catheter ablation for AVNRT. There was 100% acute success with no recurrences at a mean follow up of 32.5 months.