The high prevalence of opportunistic
infections can be attributed to the whole country because all the patients are referred to our center from all over Iran. Conclusion Reflux was the most common finding in our pediatric population with esophagitis in southern Iran. Contrary to the previous reports, the prevalence of eosinophilic esophagitis was far less than that estimated, while the prevalence of opportunistic infections was higher secondary to post-liver transplantation immunosuppression. Further studies are required to investigate the prevalence of allergic esophagitis in southern Iran. Conflict Inhibitors,research,lifescience,medical of Interest: None declared.
Background: Geographical Inhibitors,research,lifescience,medical distribution of zoonotic cutaneous leishmaniasis (ZCL)
has continuously been extended in recent years in Iran. The Beiza District is one of the newly-emerged endemic foci of ZCL in southern Iran. The main aim of the present study was to detect the vector(s) of ZCL in this area. Methods: To detect the fauna and vectors of ZCL in this district, sand flies Inhibitors,research,lifescience,medical were caught using sticky papers. Seventy randomly selected female sand flies out of 730 were molecularly investigated for Leishmania infection using species-specific nested polymerase chain reaction (PCR) assay between April and October 2010. Results: A total of 2543 sand flies were caught. The fauna was identified as 10 species (five Phlebotomus spp. and five Sergentomyia spp.). Phlebotomus papatasi was the most dominant species both indoors and outdoors (37.55% and 16.35 %, Inhibitors,research,lifescience,medical respectively). L. major was detected in 5 out of 48 investigated Phlebotomus papatasi (10.41%). Sequence-based characterization was carried out to confirm the PCR findings. The positive samples were shown to have 75-88% similarity with L. major sequences in GenBank. Conclusion: According to the findings Inhibitors,research,lifescience,medical of the present study, similar to the other foci of ZCL in Iran, P. papatasi is the proven and primary vector of CL. This study
could be drawn upon for future strategy planning in this newly emerged endemic focus. Key Words: Leishmaniasis, PCR, Sand Cell Stem Cell flies, Phlebotomus papatasi, Leishmania major, Iran Introduction Leishmaniasis represents a wide spectrum of clinical manifestations, including cutaneous (CL), mucocutaneous (MCL), OSI 744 diffused cutaneous (DCL), and visceral (VL) forms. Several variables such as parasite species, vector competence, reservoir hosts, and environmental conditions affect the epidemiology and clinical features of leishmaniasis.1,2 Different species of parasitic protozoan, Leishmania (Kinetoplastida: Trypanosomatidae), are the causal agents of this vector-borne disease. About 15 Leishmania species have been reported to cause leishmaniasis in human. Female phlebotomine sand flies (Diptera: Psychodidae) transmit these intracellular parasites to mammals via their infective bites.