The impact of an episode of acute rejection on graft function seems undeniable [20], [21] and [22]; in our series an eGFR of PD-166866 in vivo 43 ± 22.9 ml/min vs. 67.7 ± 17.9 ml/min was documented in the patients with an episode of AR vs. those patients without history of rejection. In conclusion, this information suggests that excluding sensitized patients from the DD waiting list should not be favored, although a thorough explanation and preparation of the patients for a longer time period on the waiting list should be emphasized. Although this study was carried out in a limited population, when a patient with a high

% PRA overcomes the immunological barriers for transplantation and receives a kidney, the functional graft outcomes seem to be very similar to the patients with lesser PRA percentages in the short run. However, long-term follow up is deserved to know the fate of graft and patient survival in this patient population with different pre-transplant

% PRA. The tendency for the generalization of single antigen determination in the pre-transplant screening in our setting will most likely favor the organ assignment process and prioritize adequate outcomes. As was reported by Fuggle et al., the tendency for the generalization of single antigen determination in the pre-transplant screening in our setting will most likely favor the organ assignment process RG7422 order and prioritize adequate outcomes by increasing antibody specificity definition and the understanding of a patient’s sensitization profile [23]. Bostock IC: Concept/design, data analysis/interpretation, drafting article, critical revision of article, data collection. Alberú J: Concept/design, data analysis/interpretation, drafting article, critical revision of article, approval of article, data collection. Arvizu A: Patient care, critical revision

of article, data collection. Hernandez-Mendez EA: Patient care, critical revision of article, data collection. De-Santiago A: Patient care, critical revision of article, data collection. González-Tableros N: Patient care, critical revision of article, data collection. López M: Patient care, Critical revision of article, Data collection. Castelán N: Patient care, critical revision of article, data TCL collection. Contreras AG: Patient care, critical revision of article, data collection. Morales-Buenrostro LE: Data analysis/interpretation, drafting article, critical revision of article. Gabilondo B: Data analysis/interpretation, drafting article, critical revision of article. Vilatoba M: Concept/design, data analysis/interpretation, drafting article, critical revision of article, approval of article, data collection, senior author. “
“Lung transplantation becomes the only available therapeutic option for patients with selected end-stage pulmonary diseases.