Therefore, the use of ice where coagulation is already negatively affected may carry more risk than benefit. Physiotherapy intervention is important during all phases surrounding EOS in PWHWI. However, it is crucial that the physiotherapist understand the differences between treating a person in the general population versus PWH and PWHWI to Hydroxychloroquine cost promote positive outcomes and a greater benefit than risk to these individuals. S. Rahim In developing countries,

physiotherapy is considered an integral component of the management and prevention of musculoskeletal complications as a result of recurrent joint or muscle bleeds [37]. The gold standard for physiotherapy intervention is for therapy to be performed with adequate factor replacement cover in order to minimize the risk of bleeding during treatment. In the author’s experience, factor cover is preferred in the case of inhibitor patients undergoing physical therapy. However, the inaccessibility of factor or the presence of inhibitors should not prevent

a PWH from accessing physiotherapy. There are various physiotherapy modalities and guidelines that can be utilized in the management of PWH and will be highlighted in this section. Strapping is widely used in sports and has various applications. Strapping can be used to provide support and stability and provide some proprioceptive feedback to the joint. Strapping is also widely used to inhibit or to activate various muscle groups, useful in the rehabilitation process for PWH with muscle injuries or improve muscle balancing check details between agonist and antagonist [38]. PNF uses isometric

and isotonic muscle contractions to improve range of movement and strength. It also uses functional sequential movements which can improve sequencing of muscle firing patterns. Short term use of splints especially in the acute or subacute post-bleed period can be beneficial in preventing recurrence of an injury. During gait reeducation, splints can limit the impact on various joints or muscles. C1GALT1 Prolonged injudicious use, however, can result in muscle atrophy and or joint stiffness. Orthotics can improve the biomechanical alignment of joints, improving stability, and aid in injury prevention. Caution needs to be exercised when prescribing rigid orthoses, such as knee ankle foot orthoses (KAFOs), as they can cause muscle atrophy and stiffness. They can put undue pressure on other joints and may make them more susceptible to injury. Serial casting with plaster of Paris (POP) or thermoplastic material can be used to gradually stretch and improve ROM in joints and muscles. However, these may require close follow-up in order for them to be effective and to prevent complications of casting.