③The expression of ACE2 has a negative correlation with the score of injury in pathology, p-p38MARPK and NF-κB. And the expression of AngIIhad a positive correlation with the score of injury in pathology, p-p38MARPK and NF-κB. They showed that ACE2 and AngII play an important role in the non-steroidal anti-inflammatory drugs-induced small intestinal injury. They suggest the RAS – p38MARPK signaling pathways

involved in the pathogenesis of NSAIDs-related small intestinal injury in rats. ④ Valsartan through antagonism Talazoparib cost Ang II type 1 (AT1) receptor, and then play a protection part in NSAIDs-related rat small intestinal injury. It may become a potential intervention targets in the prevention and control of NSAIDs-related small intestinal injury. Key Word(s): 1. intestinal damage; 2. NSAIDs; 3. RAS; 4. p38 MAPK; Presenting Author: VALERIA KAIBYSHEVA Additional Authors: VLADIMIR IVASHKIN, ALEXANDER TROUKHMANOV, IGOR MAEV, YURIY KUCHERYAVIY, OLGA STORONOVA Corresponding Author: ALEXANDER TROUKHMANOV, VALERIA KAIBYSHEVA Affiliations: 1st Moscow State Medical University; Moscow State University of Medicine and Dentistry Objective: GERD diagnosis remains

a challenge as both invasive methods and symptom-based strategies have limitations. The symptom-based management of GERD in primary Z-IETD-FMK in vitro care can be further optimized with the use of questionnaires. The study was conducted to assess diagnostic validity of Russian version of GerdQ (patient-centered self-assessment questionnaire) in patients with symptoms suggestive of GERD. Methods: 145 patients with symptoms suggestive of GERD completed GerdQ prior to endoscopy and

24-hour pH-metry. Reflux esophagitis and pathological acid exposure to esophagus were used as diagnostic references for GERD. Results: GerdQ sensitivity, calculated as percent (%) of patients with GerdQ score ≥8 among the patients with reflux esophagitis or pathological acid exposure, was 65.4%. GerdQ specificity, calculated as % of patients with GerdQ score among the patients with absence of esophagitis or pathological acid exposure, was 91.7%. High prevalence of reflux esophagitis (86.2%) resulted in a high positive predictive value (98.8%), but low negative predictive value (19.3%) find more for GERD. Exactness of GerdQ, calculated as ratio of right GerdQ results (true positives and true negatives) to the total number of estimated cases, was 67.6%. ROC-analysis demonstrated high sensitivity and specificity of GerdQ, AUC was 84.8% (95%CI: 71.1–98.5%). Sensitivity increased with the growth of GerdQ score; specificity was close to maximum with the score . The definite correlation between GerdQ score and prevalence of reflux esophagitis was registered. Conclusion: GerdQ is a useful complementary tool for GERD diagnosis in primary care. The implementation of GerdQ could reduce the need for upper endoscopy and improve resource utilization. Acknowledgement: The study was funded by AstraZeneca Russia Key Word(s): 1. gastro-esophageal; 2.