Metabolite N-and M-Gluc were Agomelatine Valdoxan analyzed. Although no data on the concentration of the metabolites of hydroxylation in this study, the levels of asenapine parents are based, it is likely to need during the inhibition of glucuronidation, the balance has shifted toward hydroxylation routes. The AUC of M was slightly decreased in the co-administered with valproate, which show that this approach was also to be easily affected by valproate. However, M may be further hydroxylated, and this pathway may therefore still showed activity Tw Ht during valproate treatment increased. Contribute to the pharmacological effect of Mutma Lichen metabolites asenapine unlikely in the therapeutic range of 5 to 10 mg per day. The pharmacological analysis showed that the M and N arecontrast of Gluc metabolites, the hydroxylated metabolites Similar binding profile showed asenapine, but these metabolites are not able to cross the blood-brain barrier.12 intersect Therefore, the compound without parent asenapine proposed changed to the company will be primarily responsible for the pharmacological effects of the drug. To date there is no information about the F Ability of the individual metabolites induce or inhibit CYP450 may have tzlich enzymes, and additionally the effect of this on your metabolism Either asenapine or valproate. In this interaction study, a relatively low dose of valproate hrden used so as not to safety reps and found Opportunity for healthy young people. This low dose of valproate was carried Ratings To the interaction with other drugs that are metabolized by glucuronidation.18 show, 22 The present results show that treatment was adequate with valproate 500 mg twice t Possible for 9 days to inhibit the glucuronidation of asenapine a big part of Cmax and AUC0 s 6, 6-glucuronide and 7.4 times less, but each in the combination therapy compared to treatment asenapine. Given the strong inhibition of the glucuronidation of valproate in low doses, is not expected that an hour Here would be much observed by the dose of valproate effects in this study. The aim of this study was to investigate the effect of valproate on the pharmacokinetics of asenapine, and the effects of asenapine on the pharmacokinetics of valproate have not been studied. The high inhibitory effect on glucuronidation of valproate asenapine observed schl Gt gr Affinity ere t for UGT glucuronosyltransferase valproate compared with asenapine, making it unlikely that the glucuronidation of Valproins Acid is affected by the simultaneous asenapine. In addition, the metabolism of valproate occurs for a small part in other ways Including Lich CYP2C9, CYP2C19, CYP2E1. Based on in vitro data, these roads are not affected by asenapine. The pattern of adverse events reported in this study are consistent with previously treated for asenapine4 dizziness, and 5,7,9 valproate.23, oral Par Sthesien reported dizziness and go Ren to the h Ufigsten side Honokiol effects in patients with asenapine reported acute schizophrenia or acute bipolar Mania, but the incidence in clinical trials were lower.4 are 5,7,9 reps Opportunity These results also in line with that of placebo double-blind, controlled controlled by the phase 3 clinical trials in which.