An understanding of these failures can lead to improved implant design and surgical technique.
Methods: Eighty-four consecutive patients underwent eighty-five semiconstrained total elbow arthroplasties for the treatment of posttraumatic arthritis. Sixty-nine
NU7441 mouse elbows with a retained primary prosthesis were followed for an average of nine years. Clinical results were graded with use of the Mayo Elbow Performance Score. Radiographs were assessed for mechanical failure, and all complications were recorded.
Results: Sixteen primary arthroplasties (19%) failed. Causes of failure included isolated bushing wear (seven), infection (four), component fracture (three), and component loosening (two). The most common cause of early failure (failure after less than five
years) was infection, whereas intermediate-term failure (failure after five to ten years) typically was due to bushing wear. Late failure (failure after more than ten years) was uncommon and involved component loosening or fracture. Seventy-five percent of the failures were in patients who were less than sixty years old at the time of surgery (p = 0.03). Progressive radiolucent lines were noted around four implants, three of which had clinically important loosening. Total elbow arthroplasty was associated with significant GDC-0941 concentration improvements in terms of pain, motion, and the Mayo Elbow Performance Scores (p <= 0.002). Sixty-eight percent of the patients achieved a good or excellent clinical result, and 74% were subjectively satisfied. Kaplan-Meier analysis demonstrated a fifteen-year survival rate of 70% with revision or resection for any reason as the end point.
Conclusions:
Semiconstrained total elbow arthroplasty in patients with posttraumatic arthritis places high demands on the implant and is associated with a relatively high failure rate. Seventy-five percent of failures occur in patients less than sixty years of age, and infection continues selleck screening library to represent a frequent mode of early failure. Bushing wear and component loosening or fracture are seen more commonly in the intermediate and late term, whereas aseptic loosening remains relatively uncommon.”
“Background: The therapeutic effects of immunosuppressive agents such as cyclosporin A, mycophenolate mofetil, rituximab and sirolimus on primary focal segmental glomerulosclerosis (FSGS) remain controversial. The present study was intended to review and analyze the treatment results of immunosuppressive agents for primary FSGS in child and adult patients.
Methods: Complete remission rates and partial remission rates were extracted from published articles and analyzed using statistical tests.
Results: Cyclosporin A was effective in the treatment of child and adult patients with idiopathic FSGS. Rituximab therapy displayed a higher complete remission and partial remission rate in children than in adult FSGS patients.