FGF-2-initiated signaling results in upregulation of p21WAF1/Cip1  and p27KIP1  and re-expression of integrins lost with de-differentiation , which collectively contribute to the dormant phenotype observed. Acknowledgements Supported by DAMD17-03-1-0524 (RW) and the
Ruth Estrin Goldberg Memorial for Cancer Research (RW) Open Access This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. References 1. Braun S, Pantel K, Muller P et al (2000) Cytokeratin-positive cells in the bone marrow and survival Akt inhibitor of patients with stage I, II, or III breast cancer. N Engl J Med 342:525–533CrossRefPubMed
2. Braun S, Kentenich C, Janni W et al (2000) Lack of an effect of adjuvant chemotherapy on the elimination of single dormant tumor cells in bone marrow of high risk breast cancer patients. J Clin Onc 18:80–86 3. Korah R, Boots M, Wieder R (2004) Integrin α5β1 promotes survival of breast cancer cells: an in vitro paradigm for breast cancer cell dormancy in the bone marrow. Can Res 64:4514–4522CrossRef 4. Nguyen PL, Taghian AG, Katz MS et al (2008) Breast cancer subtype approximated by estrogen receptor, progesterone this website receptor, and HER-2 is associated with local and distant recurrence after breast-conserving therapy. J Clin Oncol 26:2373–2378CrossRefPubMed 5.
Haffty BG, Yang Q, Reiss M et al (2006) Locoregional relapse and distant metastasis in conservatively managed triple negative early-stage breast cancer. J Clin Oncol 24:5652–5657CrossRefPubMed 6. Dent R, Trudeau M, Pritchard KI et al (2007) Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 13(15 Pt 1):4429–4434CrossRefPubMed 7. Cazzaniga M, Pronzato P, Leto di Priolo SL et al (2004) Patterns of relapse either and modalities of treatment of breast cancer: the ‘IRIS’ Project, a multicenter observational study. Oncology 66:260–268CrossRefPubMed 8. Nicolini A, Giardino R, Carpi A et al (2006) Metastatic breast cancer: an updating. Biomedicine & Pharmacotherapy 60:548–556CrossRef 9. Nilsson SK, Debatis ME, Dooner MS et al (1998) Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ. J Histochem & Cytochem 46:371–377 10. Van der Velde-Zimmermann D, Verdaasdonk MA, Rademakers LH et al (1997) Fibronectin distribution in human bone marrow stroma: matrix assembly and tumor cell adhesion via α5β1 integrin. Exp Cell Res 230:111–120CrossRefPubMed 11. Balduino A, Hurtado SP, Frazao P et al (2005) Bone marrow subendosteal microenvironment harbours functionally distinct haemosupportive stromal cell populations. Cell & Tissue Research 319:255–266CrossRef 12. Psaila B, Kaplan RN, Port ER et al (2006) Priming the ‘soil’ for breast cancer metastasis: the pre-metastatic niche.