For example, Petersen22 has proposed a “multiple-domain MCI” for patients exhibiting dysfunction across a range of neuropsychologic modalities,

“single nonmemory cognitive domain MCI” for patients whose cognitive symptoms reflect circumscribed impairment in a nonmemory domain, and “SGC 0946 research buy amnestic MCI” where memory loss is the predominate Inhibitors,research,lifescience,medical reason for impairment. Amnestic MCI has been proposed as the subtype most likely to portend a diagnosis of AD. Because memory symptoms are salient in most patients with early AD, this suggestion has certain face validity. Nevertheless, neuropsychological studies reveal that patients diagnosed with MCI have deficits in several cognitive domains25-29 casting suspicion on whether pure amnestic MCI, strictly speaking, actually exists. A recent European Alzheimer’s Disease Consortium/ Alzheimer’s Disease Cooperative Study (EADC/ADCS) consensus statement30,31 Inhibitors,research,lifescience,medical has expanded the initial concept of amnestic MCI to allow for the presence of other nonmemory deficits (Figure 3). In addition to eliminating cases that meet criteria for dementia, it has been suggested that MCI ought not include patients

with impairments in activities of daily living (ADL).22 The stipulation that Inhibitors,research,lifescience,medical ADL impairment should be exclusionary, however, ignores the commonly observed subtle difficulties with complex tasks requiring organization and

planning that MCI patients frequently experience.31 Thus, the EADC/ADCS revised criteria allow for mild decline in complex ADL.30,31 Requiring Inhibitors,research,lifescience,medical the presence of subjective memory complaints may also be too restrictive. Inhibitors,research,lifescience,medical Many patients with borderline dementia deny symptoms of memory loss and impaired awareness of cognitive deficits has been recently described in MCI32 In practice, reports of impairment from family members or other informants often substitute for subjective complaints by the patient. Figure 2. A conceptual model of mild cognitive impairment (MCI) as prodromal dementia. A minority of persons diagnosed with MCI may remain stable or even improve over time. Although individuals with MCI may decline to vascular or other forms of dementia, the majority … Thiamine-diphosphate kinase Figure 3. European Alzheimer’s Disease Consortium (EADC)/Alzheimer’s Disease Cooperative Study (ADCS) consensus on mild cognitive impairment (MCI) subtypes.30 In this scheme, amnestic MCI consists of cases either with memory impairment alone, or accompanied with … Regardless of how these conceptual and taxonomic problems are resolved, the successful implementation of MCI as a diagnostic category would seem to depend on the development of a precise set of definitional rules.