Gynostemma Extract after intervention after intervention P value of group A of group B Values shown in boldface are statistically significant. Withdrawal from the study and adverse events Eight participants discontinued the study. In the group A, two participants withdrew without providing a reason, two participants were lost during follow-up, and one participant withdrew because of cholelithiasis and shingles that, according to the clinical judgment, were attributed to a severe adverse event but were not related to the use of study medication. In the group B, three participants withdrew without providing a reason.
After the 3-month treatment, the concentration of serum Ca, P, and the total AKP activities Elesclomol in the two groups remained within normal ranges. Many studies have shown that 40% to % of elderly people in the US and Europe suffer from vitamin D deficiencies . More than 50% of postmenopausal women had levels of 25-hydroxyvitamin D that were lower than 30 ng per milliliter . Low levels of 25D are associated with a significant decrease in the absorption of intestinal calcium and induced secondary hyperparathyroidism . Secondary hyperparathyroidism may stimulate the transformation of preosteoclasts into mature osteoclasts, causing osteoporosis and increasing the risk of purchase travoprost fracture .
Our results show that serum Ca levels increased and serum PTH levels decreased significantly after supplementation with IU per day of cholecalciferol for three months. Kuwabara et al discovered that the supplementation of mg of calcium with IU of vitamin D 3 daily for one month significantly lowered the serum PTH lev els compared with the order Limonin supplementation of only mg of calcium daily. Seemans et al identified that in the winter, the endpoint serum PTH level to be significantly lower in 3 chole calciferol-supplemented groups compared with the placebo group, though other bone turnover markers were not affected. An increased rate of bone turnover is associated with low bone mass and an increased risk of bone fracture . Higher levels of serum CTX indicate an increase in bone resorption and bone fragility .
Total AKP is primarily a nonspecific marker of bone formation. Our results show that after supplementing with IU per day of cholecalciferol for three months, serum AKP levels increased significantly, and serum β-CTX levels decreased. These results indicate that IU per day of cholecalciferol is effective for stimulating bone formation and reducing bone resorption. Hurst et al has shown that vitamin D-deficient women who were administered wavelength 0 IU of cholecalciferol daily for 6 months displayed a suppression of age-induced bone turnover and bone resorption. However, some studies have shown cholecalciferol supplementation have no effect on bone turnover markers . Oral vitamin D supplementation increases bone mineral density and appears to reduce the risk of hip and other nonvertebral fractures. Therefore, it is reasonable to supply –0 IU/d of vitamin D to older individuals .