The retention time, mass spectrum, and tandem mass spectrum of the DME were compared with those of reference standards as well as literature data, and fifty-five components were resolved. Fourteen components were confirmed to have effects on cough and asthma. The current study aimed to establish a reliable and effective method for screening
the potentially bioactive components of CBPP, report for the first time the basis of CBPP pharmacology, and provide useful information for further studies on the CBPP mechanism of action.”
“A new approach to the spectrophotometric determination of metronidazole (MZ) and tinidazole (TZ) has been developed. The procedure involves coupling of diazotized nitroimidazoles with p-dimethylaminobenzaldehyde (DMAB) to form a greenish-yellow Belnacasan clinical trial solution. Optimal temperature and time were 0 degrees C (iced) Microbiology inhibitor and 3 minutes for diazotization and 30 degrees C and 2 minutes for coupling for both MZ and TZ. Coloured adducts of MZ and TZ showed shoulders at 406 nm and 404 nm, respectively, which were selected as analytical wavelengths. The reaction with p-DMAB occurred in a 1: 1 mole ratio. Beer’s law was obeyed within the 4.8-76.8 mu g mL(-1) concentration range with low limits of detection. The azo adducts were stable for over
a week. Molar absorptivities were 1.10 x 10(3) (MZ) and 1.30 x 10(3) L mol(-1) cm(-1) (TZ). Overall recoveries of MZ and TZ from quality control samples were 103.2 +/- 1.3 and 101.9 +/- 1.3 % over three days. There was no interference from commonly utilized tablet excipients. No significant
difference was obtained between the results of the new method and the BP titrimetric procedures. The azo approach using the p-dimethylaminobenzaldehyde Etomoxir cost procedure described in this paper is simple, fast, accurate and precise. It is the first application of DMAB as a coupling component in the diazo coupling reaction.”
“The effects of airbag deployment in motor vehicle accidents (MVA) on the fetus are poorly understood. A 22-year-old woman at 24 weeks of gestation collided with a telephone pole while driving. She was restrained and an airbag deployed. Although she had no major injuries, she experienced decreased fetal movements. Fetal heart rate (FHR) monitoring revealed loss of variability without any evidence of abruptio placentae, and 4 days later, the variability spontaneously recovered. Two weeks after the MVA, ultrasonography showed unilateral ventricular dilatation suggestive of fetal brain injury. Magnetic resonance imaging revealed subdural hematoma, intraventricular hemorrhage and cystic lesions, interpreted as indirect (hypoxic-ischemic) and direct (hemorrhagic) intracranial injuries. After MVA with airbag deployment, FHR monitoring can show a transient loss of variability, which may precede the appearance of fetal brain injury.